ArticleDiabetes2005
Homocysteine metabolism in ZDF (type 2) diabetic rats.
Article in Diabetes, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 93 citations in OpenAlex.
- Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients.PloS one · 2013Trial
- Association between serum hydrogen sulfide concentrations and dysglycemia: a population-based study.BMC endocrine disorders · 2022Article
- Hydrogen sulphide in liver glucose/lipid metabolism and non-alcoholic fatty liver disease.European journal of clinical investigation · 2022Review
- Association between plasma betaine levels and dysglycemia in patients with coronary artery disease.Bioscience reports · 2020Article
- Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes.Biochemical pharmacology · 2020Review
- Scutellarin Reduce the Homocysteine Level and Alleviate Liver Injury in Type 2 Diabetes Model.Frontiers in pharmacology · 2020Article
- Peroxisome proliferator-activated receptor A/G reprogrammes metabolism associated with lipid accumulation in macrophages.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Arsenic, one carbon metabolism and diabetes-related outcomes in the Strong Heart Family Study.Environment international · 2018Article
- Prediction of Methionine and Homocysteine levels in Zucker diabetic fatty (ZDF) rats as a T2DM animal model after consumption of a Methionine-rich diet.Nutrition & metabolism · 2018Article
- A Possible Mechanism: Vildagliptin Prevents Aortic Dysfunction through Paraoxonase and Angiopoietin-Like 3.BioMed research international · 2018Article
- NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice.Free radical biology & medicine · 2015Article
- Article
- Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice.Oxidative medicine and cellular longevity · 2015Article
- Epigenetics in adipose tissue, obesity, weight loss, and diabetes.Advances in nutrition (Bethesda, Md.) · 2014Review
- Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet.European journal of nutrition · 2013Article
- Folate deficiency is associated with oxidative stress, increased blood pressure, and insulin resistance in spontaneously hypertensive rats.American journal of hypertension · 2013Article
- Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism.PloS one · 2013Article
- Body mass and DNA promoter methylation in breast tumors in the Western New York Exposures and Breast Cancer Study.The American journal of clinical nutrition · 2011Article
- The pathogenic role of cystathionine γ-lyase/hydrogen sulfide in streptozotocin-induced diabetes in mice.The American journal of pathology · 2011Article
- T2DM: Why Epigenetics?Journal of nutrition and metabolism · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Mild hyperhomocysteinemia is a risk factor for many diseases, including cardiovascular disease. We determined the effects of insulin resistance and of type 2 diabetes on homocysteine (Hcy) metabolism using Zucker diabetic fatty rats (ZDF/Gmi fa/fa and ZDF/Gmi fa/?). Plasma total Hcy was reduced in ZDF fa/fa rats by 24% in the pre-diabetic insulin-resistant stage, while in the frank diabetic stage there was a 59% reduction. Hepatic activities of several enzymes that play a role in the removal of Hcy:cystathionine beta-synthase (CBS), cystathionine gamma-lyase, and betaine:Hcy methyltransferase (BHMT) were increased as was methionine adenosyltransferase. CBS and BHMT mRNA levels and the hepatic level of S-adenosylmethionine were also increased in the ZDF fa/fa rats. Studies with primary hepatocytes showed that Hcy export and the transsulfuration flux in cells from ZDF fa/fa rats were particularly sensitive to betaine. Interestingly, liver betaine concentration was found to be significantly lower in the ZDf fa/fa rats at both 5 and 11 weeks. These results emphasize the importance of betaine metabolism in determining plasma Hcy levels in type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.