ArticleOncogene2006
Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Hypoxia-mediated regulation of mRNA metabolism: from transcription to stability.Cell communication and signaling : CCS · 2025Review
- CTGF (CCN2): a multifaceted mediator in breast cancer progression and therapeutic targeting.Cancer metastasis reviews · 2025Review
- Analyses of the Posttranscriptional Regulation of CCN Genes: Approach to Multiple Steps of CCN2 Gene Expression.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Transfection, Spinfection, Exofection, and Luciferase Assays for Analysis of CCN Genes Expression Mechanism.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Lung fibrosis is induced in ADAR2 overexpressing mice via HuR-induced CTGF signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Tumor Hypoxia As an Enhancer of Inflammation-Mediated Metastasis: Emerging Therapeutic Strategies.Targeted oncology · 2018Review
- PCPA protects against monocrotaline-induced pulmonary arterial remodeling in rats: potential roles of connective tissue growth factor.Oncotarget · 2017Article
- Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells.Scientific reports · 2017Article
- Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers.Journal of cancer research and clinical oncology · 2016Article
- Effects of CCN3 on rat cartilage endplate chondrocytes cultured under serum deprivation in vitro.Molecular medicine reports · 2016Article
- CCN2 Expression by Tumor Stroma Is Required for Melanoma Metastasis.The Journal of investigative dermatology · 2015Article
- Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy.Journal of diabetes research · 2015Review
- 2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy.The Journal of biological chemistry · 2014Article
- Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth.Annals of hematology · 2014Article
- Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissues.Matrix biology : journal of the International Society for Matrix Biology · 2013Review
- Molecular control of vascular development by the matricellular proteinsTrends in developmental biology · 2013Article
- The role of CCN2 in cartilage and bone development.Journal of cell communication and signaling · 2011Article
- CCN2 expression and localization in melanoma cells.Journal of cell communication and signaling · 2011Article
- The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis.Critical reviews in eukaryotic gene expression · 2011Review
- Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors.BMC cancer · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Connective tissue growth factor (CTGF/CCN2) can be induced by various forms of stress such as exposure to high glucose, mechanical load, or hypoxia. Here, we investigated the molecular mechanism involved in the induction of ctgf/ccn2 by hypoxia in a human chondrosarcoma cell line, HCS-2/8. Hypoxia increased the ctgf/ccn2 mRNA level by altering the 3'-untranslated region (UTR)-mediated mRNA stability without requiring de novo protein synthesis. After a series of extensive analyses, we eventually found that the cis-repressive element of 84 bases within the 3'-UTR specifically bound to a cytoplasmic/nuclear protein. By conducting a UV crosslinking assay, we found the cytoplasmic/nuclear protein to be a 35 kDa molecule that bound to the cis-element in a hypoxia-inducible manner. These results suggest that a cis-element in the 3'-UTR of ctgf/ccn2 mRNA and trans-factor counterpart(s) play an important role in the post-transcriptional regulation by determining the stability of ctgf/ccn2 mRNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.