ReviewNeuromolecular medicine2005
Controlled autoimmunity in CNS maintenance and repair: naturally occurring CD4+CD25+ regulatory T-Cells at the crossroads of health and disease.
Review in Neuromolecular medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Microglial crosstalk with astrocytes and immune cells in amyotrophic lateral sclerosis.Frontiers in immunology · 2023Review
- Trauma induces expansion and activation of a memory-like Treg population.Journal of leukocyte biology · 2021Article
- The Need for Physiological Micro-Nanofluidic Systems of the Brain.Frontiers in bioengineering and biotechnology · 2019Review
- Regulatory T Cells in Post-stroke Immune Homeostasis.Translational stroke research · 2016Review
- Review
- State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.ALTEX · 2014Review
- Microglial dysregulation in psychiatric disease.Clinical & developmental immunology · 2013Review
- The Neuroinflammatory Response in ALS: The Roles of Microglia and T Cells.Neurology research international · 2012Article
- Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis.Brain : a journal of neurology · 2011Article
- Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury.Journal of leukocyte biology · 2011Article
- T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?Trends in immunology · 2010Review
- Influence of age on behavioral, immune and endocrine responses to the T-cell superantigen staphylococcal enterotoxin A.The European journal of neuroscience · 2009Article
- CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Cognitive disorders in mice: cytokine signaling pathways as therapeutic targets.Omics : a journal of integrative biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T-cells directed to self-antigens ("autoimmune" T-cells) have traditionally been perceived as tending to attack the body's own tissues, and likely to exert their destructive effects unless they undergo deletion in the thymus during ontogeny. Naturally occurring CD4+CD25+ regulatory T-cells were viewed as thymus-derived cells that constitutively suppress any autoimmune T-cells that escaped thymic deletion. Studies in recent years suggest, however, that some autoimmune T-cells are necessary, at least in the central nervous system for neural maintenance and repair, possibly in part by rendering the resident microglia capable of fighting off adverse conditions, as well as for neural maintenance and repair. In line with this notion, the regulatory T-cells are thought to allow autoimmunity to exist in healthy individuals without causing an autoimmune disease. This proposed immune scenario and its implications for therapy are discussed.
Indexed as
Identifiers
16247180What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.