ArticleThe Journal of cell biology2005
Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Ocular Manifestations in Patients with Werner Syndrome.International journal of molecular sciences · 2026Review
- Aging of the human eye lens: Epigenetic landscape and therapeutic targets in age‑related cataracts (Review).International journal of molecular medicine · 2025Review
- Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts.Nucleic acids research · 2024Article
- The role of DDK and Treslin-MTBP in coordinating replication licensing and pre-initiation complex formation.Open biology · 2021Article
- Ensemble and Single-Molecule Analysis of Non-Homologous End Joining in Frog Egg Extracts.Methods in enzymology · 2017Article
- CDK1 phosphorylates WRN at collapsed replication forks.Nature communications · 2016Article
- Epigenetic Regulation of Werner Syndrome Gene in Age-Related Cataract.Journal of ophthalmology · 2015Article
- DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.The Journal of biological chemistry · 2014Article
- Structural mechanisms of human RecQ helicases WRN and BLM.Frontiers in genetics · 2014Review
- Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population.Age (Dordrecht, Netherlands) · 2013Article
- Article
- Role of the checkpoint clamp in DNA damage response.Biomolecules · 2013Article
- Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair.The Journal of cell biology · 2011Article
- Replication protein A promotes 5'-->3' end processing during homology-dependent DNA double-strand break repair.The Journal of cell biology · 2011Article
- Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends.Nucleic acids research · 2008Article
- Intrinsic ssDNA annealing activity in the C-terminal region of WRN.Biochemistry · 2008Article
- Two closely related RecQ helicases have antagonistic roles in homologous recombination and DNA repair in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution.Genome biology · 2007Article
- Host cell DNA repair pathways in adeno-associated viral genome processing.Journal of virology · 2006Article
- Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability.The Biochemical journal · 2006Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Werner syndrome is associated with premature aging and increased risk of cancer. Werner syndrome protein (WRN) is a RecQ-type DNA helicase, which seems to participate in DNA replication, double-strand break (DSB) repair, and telomere maintenance; however, its exact function remains elusive. Using Xenopus egg extracts as the model system, we found that Xenopus WRN (xWRN) is recruited to discrete foci upon induction of DSBs. Depletion of xWRN has no significant effect on nonhomologous end-joining of DSB ends, but it causes a significant reduction in the homology-dependent single-strand annealing DSB repair pathway. These results provide the first direct biochemical evidence that links WRN to a specific DSB repair pathway. The assay for single-strand annealing that was developed in this study also provides a powerful biochemical system for mechanistic analysis of homology-dependent DSB repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.