ArticleProceedings of the National Academy of Sciences of the United States of America2005
Breath sulfides and pulmonary function in cystic fibrosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Clinical use of exhaled volatile organic compounds in pulmonary diseases: a systematic review.Respiratory research · 2012Pooled it
- Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide.British journal of clinical pharmacology · 2010Trial
- Exhaled Breath Analysis for Detection of Interstitial Lung Diseases Using Real-Time PTR-TOF-MS.International journal of molecular sciences · 2026Article
- Exploring the Reactivity of Electrophilic Organic Carbonates and Thiocarbonates as Vehicles to Convert Hydrosulfide into COS and CSThe Journal of organic chemistry · 2024Article
- Article
- Thiol-Activated 1,2,4-Thiadiazolidin-3,5-diones Release Hydrogen Sulfide through a Carbonyl-Sulfide-Dependent Pathway.The Journal of organic chemistry · 2022Article
- Volatolomics in healthcare and its advanced detection technology.Nano research · 2022Review
- Breath-Taking Perspectives and Preliminary Data toward Early Detection of Chronic Liver Diseases.Biomedicines · 2021Review
- Metabolic Phenotypes in Asthmatic Adults: Relationship with Inflammatory and Clinical Phenotypes and Prognostic Implications.Metabolites · 2021Review
- Measurement Device for Ambient Carbonyl Sulfide by Means of Catalytic Reduction Followed by Wet Scrubbing/Fluorescence Detection.ACS omega · 2020Article
- Progress toward colorimetric and fluorescent detection of carbonyl sulfide.Chemical communications (Cambridge, England) · 2020Article
- Esterase-Triggered Self-Immolative Thiocarbamates Provide Insights into COS Cytotoxicity.ACS chemical biology · 2019Article
- Emerging Roles of Carbonyl Sulfide in Chemical Biology: Sulfide Transporter or Gasotransmitter?Antioxidants & redox signaling · 2018Review
- Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/HACS chemical biology · 2017Article
- Article
- Article
- A Winogradsky-based culture system shows an association between microbial fermentation and cystic fibrosis exacerbation.The ISME journal · 2015Article
- Advances in electronic-nose technologies for the detection of volatile biomarker metabolites in the human breath.Metabolites · 2015Review
- Breath analysis as a potential and non-invasive frontier in disease diagnosis: an overview.Metabolites · 2015Review
- Breath gas metabolites and bacterial metagenomes from cystic fibrosis airways indicate active pH neutral 2,3-butanedione fermentation.The ISME journal · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
We have determined the concentrations of carbonyl sulfide (OCS), dimethylsulfide, and carbon disulfide (CS(2)) in the breath of a group of cystic fibrosis (CF) patients and one of healthy controls. At the detection sensitivity in these experiments, room air always contained measurable quantities of these three gases. For each subject the inhaled room concentrations were subtracted from the time-coincident concentrations in exhaled breath air. The most significant differences between the CF and control cohorts in these breath-minus-room values were found for OCS. The control group demonstrated a net uptake of 250 +/- 20 parts-per-trillion-by-volume (pptv), whereas the CF cohort had a net uptake of 110 +/- 60 pptv (P = 0.00003). Three CF patients exhaled more OCS than they inhaled from the room. The OCS concentrations in the CF cohort were strongly correlated with pulmonary function. The dimethylsulfide concentrations in breath were greatly enhanced over ambient, but no significant difference was observed between the CF and healthy control groups. The net (breath minus room) CS(2) concentrations for individuals ranged between +180 and -100 pptv. They were slightly greater in the CF cohort (+26 +/- 38 pptv) vs. the control group (-17 +/- 15 pptv; P = 0.04). Lung disease in CF is accompanied by the subsistence of chronic bacterial infections. Sulfides are known to be produced by bacteria in various systems and were therefore the special target for this investigation. Our results suggest that breath sulfide content deserves attention as a noninvasive marker of respiratory colonization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.