ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2005
Distinct regulatory elements mediate the dynamic expression pattern of Nkx3.1.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Prostatic lineage differentiation from human embryonic stem cells through inducible expression of NKX3-1.Stem cell research & therapy · 2024Article
- Downregulation of C-Terminal Tensin-Like Protein (CTEN) Suppresses Prostate Cell Proliferation and Contributes to Acinar Morphogenesis.International journal of molecular sciences · 2018Article
- Prostate Organogenesis.Cold Spring Harbor perspectives in medicine · 2018Review
- Transcriptional regulation of theThe Journal of biological chemistry · 2017Article
- Prostate organogenesis: tissue induction, hormonal regulation and cell type specification.Development (Cambridge, England) · 2017Review
- Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer.Cancer research · 2016Article
- Essential roles of epithelial bone morphogenetic protein signaling during prostatic development.Endocrinology · 2014Article
- Canonical Wnt signaling regulates Nkx3.1 expression and luminal epithelial differentiation during prostate organogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Visualization and quantification of mouse prostate development by in situ hybridization.Differentiation; research in biological diversity · 2012Article
- PI3K/mTOR signaling regulates prostatic branching morphogenesis.Developmental biology · 2011Article
- MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells.PloS one · 2010Article
- Androgenic regulation of ventral epithelial bud number and pattern in mouse urogenital sinus.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Intronic DNA elements regulate androgen-dependent expression of the murine Nkx3.1 gene.Gene expression · 2010Article
- Article
- Hoxb13 regulatory elements mediate transgene expression during prostate organogenesis and carcinogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Integrating differentiation and cancer: the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis.Differentiation; research in biological diversity · 2008Review
- Molecular signaling pathways that regulate prostate gland development.Differentiation; research in biological diversity · 2008Review
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Loss of Nkx3.1 function in mice results in defects in prostate development and epithelial hyperplasia, indicating that this gene plays important roles in both the initiation and maintenance of prostate differentiation. In humans, decreased NKX3.1 expression is associated with the progression of prostate cancer. Despite these roles in prostate development and disease, the transcriptional regulation of Nkx3.1 has not been systematically addressed. A reporter gene approach in transgenic mice was used to identify regulatory regions that dictate the expression pattern of Nkx3.1. A 32-kb DNA fragment from the Nkx3.1 locus that specifies the expected expression pattern during embryogenesis and postnatal life has been identified. Deletion analyses demonstrated that cis-regulatory elements that mediate expression in distinct sites are separable. A 5-kb fragment downstream of the Nkx3.1 coding region contains elements that support expression in the prostate and bulbourethral glands, whereas an upstream fragment contains elements that direct expression in somites and testes. Reporter gene expression analyses also revealed several previously unknown sites of Nkx3.1 expression in males, including urethral glands, glandular cells in the urethral diverticulum and basal epithelial cells in the prostate. In addition, these analyses revealed Nkx3.1 expression in female urethral glands. The identification of Nkx3.1 cis-regulatory elements provides a unique starting point to dissect signaling pathways involved in prostate organogenesis and pathogenesis and provides a system to perturb gene expression throughout prostate development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.