ArticleTransgenic research2005
Mammary specific transgenic over-expression of insulin-like growth factor-I (IGF-I) increases pig milk IGF-I and IGF binding proteins, with no effect on milk composition or yield.
Article in Transgenic research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Transcriptomic and metabolomic profiles reveal the functions of IGF-1 c.258 A > G synonymous mutation in milk fat content.Journal of advanced research · 2026Article
- Effects of combining increased lysine (protein) supply in late gestation and domperidone in lactation on sow and piglet performances.Journal of animal science · 2025Article
- A review of transgenic animal techniques and their applications.Journal, genetic engineering & biotechnology · 2023Review
- Exogenous porcine somatotropin stimulates mammary development in late-pregnant gilts.Journal of animal science · 2019Article
- Production GH transgenic goat improving mammogenesis by somatic cell nuclear transfer.Molecular biology reports · 2014Article
- Association between LEPR and MC4R genes polymorphisms and composition of milk from sows of dam line.Molecular biology reports · 2013Article
- Precision editing of large animal genomes.Advances in genetics · 2012Review
- Article
- Zebrafish eggs used as bioreactors for the production of bioactive tilapia insulin-like growth factors.Transgenic research · 2011Article
- Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?Transgenic research · 2010Article
- A high protein moderate carbohydrate diet fed at discrete meals reduces early progression of N-methyl-N-nitrosourea-induced breast tumorigenesis in rats.Nutrition & metabolism · 2010Article
- The declining phase of lactation: peripheral or central, programmed or pathological?Journal of mammary gland biology and neoplasia · 2007Review
- Pigs taking wing with transposons and recombinases.Genome biology · 2007Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
IGF-I regulates lactation by stimulating mammary mitogenesis, inhibiting apoptosis, and partially mediating the effects of growth hormone on lactogenesis. Herein, lactation performance during first and second parity was assessed in transgenic swine (TG) that over-expressed human IGF-I in milk under the control of the bovine alpha-lactalbumin promoter, regulatory regions and signal peptide coding sequence. Milk samples were collected throughout lactation (farrowing to d24) from TG sows and non-transgenic littermates (CON) and IGF-I, IGF-II, and IGFBP determined. Colostral (<24 h postpartum) IGF-I content was 26-fold greater (p<0.001) in TG sows (949+/- 107 microg/L; range 228-1,600 microg/L) than CON (36+/-17.8 microg/L) and was 50- to 90-fold greater (p< 0.001) in mature milk (d2-24 postpartum). There was no effect of parity on milk IGF-I content. Milk IGF-II concentration was unaffected by IGF-I over-expression. Low molecular weight IGFBP (IGFBP-2 and -5) in the milk of TG sows were higher (p=0.02) than CON in the early postpartum period, but did not differ in mature milk. Milk yield, determined by weigh-suckle-weigh, was similar in TG and CON as was litter weight gain. Milk nutrient composition was not significantly affected by IGF over-expression. Thus, mammary specific transgenic over-expression of IGF-I significantly increased milk IGF-I and IGFBP content, but did not impact lactation performance in swine.
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Registered trials
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