ReviewTransgenic research2005
Engineering disease resistant cattle.
Review in Transgenic research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 87 citations in OpenAlex.
- Comparative genomic analysis ofMicrobial genomics · 2025Article
- The occurrence ofmSystems · 2024Article
- A longitudinal census of the bacterial community in raw milk correlated with Staphylococcus aureus clinical mastitis infections in dairy cattle.Animal microbiome · 2022Article
- Antimicrobial peptides: features, applications and the potential use against covid-19.Molecular biology reports · 2022Review
- Towards progressive regulatory approaches for agricultural applications of animal biotechnology.Transgenic research · 2022Review
- Comparative genomic analysis ofMicrobial genomics · 2021Article
- Staphylococcus aureus in Agriculture: Lessons in Evolution from a Multispecies Pathogen.Clinical microbiology reviews · 2021Review
- Genome-wide DNA methylation pattern in a mouse model reveals two novel genes associated with Staphylococcus aureus mastitis.Asian-Australasian journal of animal sciences · 2020Article
- Applications of mesenchymal stem cell technology in bovine species.Stem cell research & therapy · 2019Review
- Identification of a novel mechanism of action of bovine IgG antibodies specific for Staphylococcus aureus.Veterinary research · 2018Article
- Cattle infection response network and its functional modules.BMC immunology · 2018Article
- Study on the accuracy of milk amyloid A test and other diagnostic methods for identification of milk quality.Veterinary research forum : an international quarterly journal · 2018Article
- First study of sperm mediated gene transfer in Egyptian river buffalo.Journal, genetic engineering & biotechnology · 2017Article
- Prevalence and pathogens of subclinical mastitis in dairy goats in China.Tropical animal health and production · 2015Article
- Genome engineering in cattle: recent technological advancements.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Effect of management practices and animal age on incidence of mastitis in Nili Ravi buffaloes.Tropical animal health and production · 2014Article
- Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans.The FEBS journal · 2014Article
- Gene and protein sequence optimization for high-level production of fully active and aglycosylated lysostaphin in Pichia pastoris.Applied and environmental microbiology · 2014Article
- Risks factors associated with subclinical mastitis in water buffaloes in Pakistan.Tropical animal health and production · 2013Article
- Stem cell research: a novel boulevard towards improved bovine mastitis management.International journal of biological sciences · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mastitis is a disease of the mammary gland caused by pathogens that find their way into the lumen of the gland through the teat canal. Mammary gland infections cost the US dairy industry approximately $2 billion dollars annually and have a similar impact in Europe. In the absence of effective treatments or breeding strategies to enhance mastitis resistance, we have created transgenic dairy cows that express lysostaphin in their mammary epithelium and secrete the antimicrobial peptide into milk. Staphylococcus aureus, a major mastitis pathogen, is exquisitely sensitive to lysostaphin. The transgenic cattle resist S. aureus mammary gland challenges, and their milk kills the bacteria, in a dose dependent manner. This first step in protecting cattle against mastitis will be followed by introduction of other genes to deal with potential resistance issues and other mastitis causing organisms. Care will be taken to avoid altering milk's nutritional and manufacturing properties. Multi-cistronic constructs may be required to achieve our goals as will other strategies possibly involving RNAi and gene targeting technology. This work demonstrates the possibility of using transgenic technology to address disease problems in agriculturally important species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.