ArticleMammalian genome : official journal of the International Mammalian Genome Society2005
Quantitative trait loci for hip dysplasia in a cross-breed canine pedigree.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Across-breed genetic investigation of canine hip dysplasia, elbow dysplasia, and anterior cruciate ligament rupture using whole-genome sequencing.Frontiers in genetics · 2022Article
- Genetic Variability in Polish Lowland Sheepdogs Assessed by Pedigree and Genomic Data.Animals : an open access journal from MDPI · 2020Article
- The association of genetic polymorphisms of bone formation genes with canine hip dysplasia.Iranian journal of veterinary research · 2020Article
- Effectiveness of Canine Hip Dysplasia and Elbow Dysplasia Improvement Programs in Six UK Pedigree Breeds.Frontiers in veterinary science · 2019Article
- Phenotypic hip and elbow dysplasia trends in Rottweilers and Labrador retrievers in South Africa (2007-2015): Are we making progress?Journal of the South African Veterinary Association · 2017Article
- Article
- Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait mapping.Disease models & mechanisms · 2016Article
- Emerging insights into the genetic basis of canine hip dysplasia.Veterinary medicine (Auckland, N.Z.) · 2015Review
- A genetic predictive model for canine hip dysplasia: integration of Genome Wide Association Study (GWAS) and candidate gene approaches.PloS one · 2015Article
- Diagnosis, prevention, and management of canine hip dysplasia: a review.Veterinary medicine (Auckland, N.Z.) · 2015Review
- Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers.BMC genomics · 2014Article
- Multiple loci associated with canine hip dysplasia (CHD) in German shepherd dogs.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Article
- Identification and validation of quantitative trait loci (QTL) for canine hip dysplasia (CHD) in German Shepherd Dogs.PloS one · 2014Article
- Monitoring Hip and Elbow Dysplasia achieved modest genetic improvement of 74 dog breeds over 40 years in USA.PloS one · 2013Article
- Article
- Identification of quantitative trait loci (QTL) for canine hip dysplasia and canine elbow dysplasia in Bernese mountain dogs.PloS one · 2012Article
- Canine hip dysplasia is predictable by genotyping.Osteoarthritis and cartilage · 2011Article
- Directional asymmetry in the limbs, skull and pelvis of the silver fox (V. vulpes).Journal of morphology · 2010Article
- Genetic evaluation of hip score in UK Labrador Retrievers.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
Canine hip dysplasia is a common developmental inherited trait characterized by hip laxity, subluxation or incongruity of the femoral head and acetabulum in affected hips. The inheritance pattern is complex and the mutations contributing to trait expression are unknown. In the study reported here, 240 microsatellite markers distributed in 38 autosomes and the X chromosome were genotyped on 152 dogs from three generations of a crossbred pedigree based on trait-free Greyhound and dysplastic Labrador Retriever founders. Interval mapping was undertaken to map the QTL underlying the quantitative dysplastic traits of maximum passive hip laxity (the distraction index), the dorsolateral subluxation score, and the Norberg angle. Permutation testing was used to derive the chromosome-wide level of significance at p<0.05 for each QTL. Chromosomes 4, 9, 10, 11 (p<0.01), 16, 20, 22, 25, 29 (p<0.01), 30, 35, and 37 harbor putative QTL for one or more traits. Successful detection of QTL was due to the cross-breed pedigree, multiple-trait measurements, control of environmental background, and marked advancement in canine mapping tools.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.