ArticleJournal of molecular evolution2005
Sex-specific functional specialization and the evolutionary rates of essential fertility genes.
Article in Journal of molecular evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Sexual Selection on Non-Ornamental Traits Is Underpinned by Evidence of Genetic Constraints on Sex-Biased Expression in Dusky Pipefish.Molecular ecology · 2025Article
- Genes and genomes and unnecessary complexity in precision medicine.NPJ genomic medicine · 2020Review
- Effects of different kinds of essentiality on sequence evolution of human testis proteins.Scientific reports · 2017Article
- Colloquium papers: Heritability of reproductive fitness traits in a human population.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Adaptive evolution of proteins secreted during sperm maturation: an analysis of the mouse epididymal transcriptome.Molecular biology and evolution · 2008Article
- Asymmetry and polymorphism of hybrid male sterility during the early stages of speciation in house mice.Evolution; international journal of organic evolution · 2008Article
- Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness.American journal of human genetics · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes related to sex and reproduction are known to evolve rapidly, however, the mechanism for rapid evolutionary change is proving to be more complex than a simple relaxation of selective constraint. We compared the divergence between orthologous human and mouse fertility genes according to their degree of dispensability as suggested by mouse knockout mutation phenotypes. The dataset consisted of 161 orthologous genes affecting fertility and 803 orthologous genes affecting viability. We find that essential fertility genes affecting both sexes evolve at a similar rate as essential viability genes, but that within sexes the degree of dispensability is not an important factor affecting the rate of fertility gene evolution. We also find no difference in the evolutionary rates of fertility genes that affect the male versus the female, however, there are a greater number of sterility genes that affect the male. Generally there are a significantly greater number of fertility genes that affect one sex rather than both, suggesting that fertility genes tend toward sex-specific functions, particularly in the male. Our findings support the hypothesis that the rapid evolution of sex- and reproduction-related genes is facilitated through an increased specialization of gene function and that dispensability is not a major factor determining their evolutionary rate.
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