ArticleMycopathologia2005
Characterization of the ALP1 gene locus of Trichophyton tonsurans.
Article in Mycopathologia, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Divergence among an international population of Trichophyton tonsurans isolates.Mycopathologia · 2010Article
- Griseofulvin Only Modestly Diminishes Persistence of Trichophyton tonsurans on the Scalp of Carriers.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2009Article
- A large outbreak of Trichophyton tonsurans among health care workers in a pediatric hospital.American journal of infection control · 2009Article
- Multilocus genotyping identifies infections by multiple strains of Trichophyton tonsurans.Journal of clinical microbiology · 2007Article
- Strain differentiation of dermatophytes.MycopathologiaReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Trichophyton tonsurans is the primary etiologic agent of fungal infections in the pediatric population. Establishing techniques that facilitate strain discrimination offer the opportunity to investigate the relationship between fungal genotype, biochemical phenotype and disease presentation in the host. In the process of expanding efforts to elucidate intra-specific genetic variability in T. tonsurans, we have identified 2 genetic polymorphisms in the ALP1 gene: a fragment length polymorphism in the 5'UTR and a single SNP (G-->A) within the 3'UTR. Full sequence data revealed that the length polymorphism was constituted by a 16 bp repeat element, present in tandem from 3 to 6 times depending on the strain. Quantitative RT-PCR analysis demonstrated a clear association between the length polymorphism and ALP1 mRNA transcript levels. Not only do the sequence variations identified in this study increase our ability to discriminate T. tonsurans strains, but they also reveal the presence of a genetic variation with functional consequences at the transcript level that may play a role in regulating disease severity.
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Registered trials
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