ArticleBritish journal of sports medicine2005
Release of alpha-actin into serum after skeletal muscle damage.
Article in British journal of sports medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 48 citations in OpenAlex.
- The ACTN3 genotype in soccer players in response to acute eccentric training.European journal of applied physiology · 2012Trial
- Systemic Integrative Mechanisms and Intervention Strategies in Exercise-Induced Skeletal Muscle Damage: Evidence from Animal, Clinical, and Multi-Omics Studies.International journal of molecular sciences · 2026Review
- Immunoglobulin G complexes from post-infectious ME/CFS, including post-COVID ME/CFS disrupt cellular energetics and alter inflammatory marker secretion.Brain, behavior, & immunity - health · 2026Article
- IBS008738, a TAZ activator, facilitates muscle repair and inhibits muscle injury in a mouse model of sport-induced injury.Cytotechnology · 2025Article
- Effects of two-week machine massage on muscle properties in adolescent wrestlers.Frontiers in physiology · 2023Article
- Potential Muscle-Related Biomarkers in Predicting Curve Progression to the Surgical Threshold in Adolescent Idiopathic Scoliosis-A Pilot Proteomic Study Comparing Four Non-Progressive vs. Four Progressive Patients vs. A Control Cohort.Journal of clinical medicine · 2021Article
- Stimuli-Responsive Delivery of Growth Factors for Tissue Engineering.Advanced healthcare materials · 2020Review
- Plasma Actin, Gelsolin and Orosomucoid Levels after Eccentric Exercise.Journal of human kinetics · 2017Article
- Effect of nuclear factor κB inhibition on serotype 9 adeno-associated viral (AAV9) minidystrophin gene transfer to the mdx mouse.Molecular medicine (Cambridge, Mass.) · 2012Article
- Development aggravates the severity of skeletal muscle catabolism induced by endotoxemia in neonatal pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Role of alpha-actin in muscle damage of injured athletes in comparison with traditional markers.British journal of sports medicine · 2007Article
- Immunoglobulin responses to a repeated bout of downhill running.British journal of sports medicine · 2006Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe skeletal muscle protein alpha-actin was investigated in the serum of subjects with severe skeletal muscle damage to assess its utility as a reliable and predictive marker of muscle damage.
methodsSerum samples were obtained from 33 healthy controls and 33 patients with severe skeletal muscle damage, defined by a total creatine kinase value of >500 IU/l (Rosalki method). Troponin I, troponin T, and myoglobin concentrations were determined by immunoassay and alpha-actin concentrations by Western blot and densitometry.
resultsThe mean serum concentration of alpha-actin in controls and patients with skeletal muscle damage was 600.9 and 1968.51 ng/ml, respectively, a statistically significant difference. Sera of patients with muscle damage showed higher levels of alpha-actin than of troponin or myoglobin. No significant difference in troponin I levels was observed between the groups.
conclusionsAccording to these results, alpha-actin was the most significant skeletal muscle damage marker analysed and may be an ideal candidate for the identification of all types of myofibre injury, including sports injuries. Our findings support the use of alpha-actin as a marker alongside other currently used biological proteins.
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