Evidence map›Paper›PMID 16243993›Full record

SynthesisAnesthesia and analgesia2005

Does neostigmine administration produce a clinically important increase in postoperative nausea and vomiting?

Ching-Rong Cheng, Daniel I Sessler, Christian C Apfel

Registry-linked trialOpen access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Anesthesia and analgesia, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02860507 (A Randomized, Blinded-assessor, Single Center Study to Determine if Administration of Sugammadex, When Used to Reverse Deep Neuromuscular Blockade), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02860507 phase4completednot on this mapstarted 2016, after this paper: background citation

A Randomized, Blinded-assessor, Single Center Study to Determine if Administration of Sugammadex, When Used to Reverse Deep Neuromuscular Blockade (NMB) After Open Abdominal Surgery, Impacts Hospital Efficiency

TypeinterventionalSponsorUniversity of South FloridaRan2016 to 2018Enrolled50ConditionsNeuromuscular BlockadeArmssugammadex, Neostigmine, Glycopyrrolate
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.

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  18. Postoperative nausea and vomiting following orthognathic surgery.International journal of oral and maxillofacial surgery · 2015
    Article
  19. Benefits and risks of sugammadex.Korean journal of anesthesiology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ching-Rong ChengOutcomes Research Institute and Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, Kentucky.
Daniel I Sessler
Christian C Apfel
University of Louisville · US

Funding

Nitrous Oxide and Wound InfectionsR01GM061655 · NIGMS · UNIVERSITY OF LOUISVILLE · PI AKCA, OZAN · 2003 to 2006
$437k
NIGMS NIH HHS GM 0616555NIGMS NIH HHS R01 GM061655NIGMS NIH HHS R01 GM061655-03
6 · The paper itself

Abstract

Neostigmine is used to antagonize neuromuscular blocker-induced residual neuromuscular paralysis. Despite the findings of a previous meta-analysis, the effect of neostigmine on postoperative nausea and vomiting remains unresolved. We reevaluated the effect of neostigmine on postoperative nausea and vomiting while considering the different anticholinergics as potentially confounding factors. We performed a systematic literature search using MEDLINE, Embase, Cochrane library, reference listings, and hand searching with no language restriction through December 2004 and identified 10 clinical, randomized, controlled trials evaluating neostigmine's effect on postoperative nausea and vomiting. Data on nausea or vomiting from 933 patients were extracted for the early (0-6 h), delayed (6-24 h), and overall (0-24 h) postoperative periods and analyzed with RevMan 4.2 (Cochrane Collaboration, Oxford, UK) and multiple logistic regression analysis. The combination of neostigmine with either atropine or glycopyrrolate did not significantly increase the incidence of overall (0-24 h) vomiting (relative risk, 0.91; 95% confidence interval, 0.70-1.18; P = 0.48) or nausea (relative risk, 1.24; 95% confidence interval, 0.98-1.59; P = 0.08). Multiple logistic regression analysis indicated that there was not a significant increase in the risk of vomiting with large compared with small doses of neostigmine. Contrasting a previous analysis, we conclude that there is insufficient evidence to conclude that neostigmine increases the risk of postoperative nausea and vomiting.

Indexed as

HumansLogistic ModelsNeostigmineNeuromuscular Blocking AgentsPostoperative Nausea and VomitingNeostigmineNeuromuscular Blocking Agents

Identifiers

PMID16243993
PMCPMC1458621
OpenAlexW2010741345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.