ArticleThe Plant cell2005
Maize rough sheath2 and its Arabidopsis orthologue ASYMMETRIC LEAVES1 interact with HIRA, a predicted histone chaperone, to maintain knox gene silencing and determinacy during organogenesis.
Article in The Plant cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
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Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.
- Integrated QTL Mapping, Meta-Analysis, and RNA-Sequencing Reveal Candidate Genes for Maize Deep-Sowing Tolerance.International journal of molecular sciences · 2023Pooled it
- Genome-wide characterization of the LBD gene family in Sapindus mukorossi and functional analysis of the role of SmuLBD26 in male sterility.Plant cell reports · 2026Article
- Transcriptomic Analysis of Phylloclade inPlants (Basel, Switzerland) · 2026Article
- Evolutionary Conservation and Regulatory Diversification ofInternational journal of molecular sciences · 2025Article
- Unlocking grass leaf development: foundations for tunable cereal design.The New phytologist · 2025Review
- CRISPR/Cas9-Mediated Targeted Mutagenesis ofInternational journal of molecular sciences · 2025Article
- Functional Characterization of KNOX and BELL Genes in Temperature-Responsive Floral Morphogenesis of Passion Fruit (Plants (Basel, Switzerland) · 2025Article
- Mapping of identity by descent reveals genes shaping morphology and biological traits in the cultivated lettuce varieties during the long-term crossbreeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Arabidopsis ASYMMETRIC LEAVES2 and Nucleolar Factors Are Coordinately Involved in the Perinucleolar Patterning of AS2 Bodies and Leaf Development.Plants (Basel, Switzerland) · 2023Article
- The plant stem-cell niche and pluripotency: 15 years of an epigenetic perspective.Frontiers in plant science · 2022Article
- Repression of a large number of genes requires interplay between homologous recombination and HIRA.Nucleic acids research · 2021Article
- Overexpression of a Pak Choi Gene,Genes · 2021Article
- Article
- Using single-plant-omics in the field to link maize genes to functions and phenotypes.Molecular systems biology · 2020Article
- Roles of ASYMMETRIC LEAVES2 (AS2) and Nucleolar Proteins in the Adaxial-Abaxial Polarity Specification at the Perinucleolar Region in Arabidopsis.International journal of molecular sciences · 2020Review
- The formation of perinucleolar bodies is important for normal leaf development and requires the zinc-finger DNA-binding motif in Arabidopsis ASYMMETRIC LEAVES2.The Plant journal : for cell and molecular biology · 2020Article
- Coordination of Leaf Development Across Developmental Axes.Plants (Basel, Switzerland) · 2019Review
- Identification of transcription factor binding sites on promoter ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2019Article
- Regulation of Plant Growth and Development: A Review From a Chromatin Remodeling Perspective.Frontiers in plant science · 2018Review
- SPL13 regulates shoot branching and flowering time in Medicago sativa.Plant molecular biology · 2018Article
37 more citing papers are in PubMed but not listed here.
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant shoots are characterized by indeterminate growth resulting from the action of a population of stem cells in the shoot apical meristem (SAM). Indeterminacy within the SAM is specified in part by the class I knox homeobox genes. The myb domain proteins rough sheath2 (RS2) and ASYMMETRIC LEAVES1 (AS1) from maize (Zea mays) and Arabidopsis thaliana, respectively, are required to establish determinacy during leaf development. These proteins are part of a cellular memory system that in response to a stem cell-derived signal keeps knox genes in an off state during organogenesis. Here, we show that RS2/AS1 can form conserved protein complexes through interaction with the DNA binding factor ASYMMETRIC LEAVES2, a predicted RNA binding protein (RIK, for RS2-Interacting KH protein), and a homologue of the chromatin-remodeling protein HIRA. Partial loss of HIRA function in Arabidopsis results in developmental defects comparable to those of as1 and causes reactivation of knox genes in developing leaves, demonstrating a direct role for HIRA in knox gene repression and the establishment of determinacy during leaf formation. Our data suggest that RS2/AS1 and HIRA mediate the epigenetic silencing of knox genes, possibly by modulating chromatin structure. Components of this process are conserved in animals, suggesting the possibility that a similar epigenetic mechanism maintains determinacy during both plant and animal development.
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