Evidence map›Paper›PMID 16242050›Full record

ReviewCurrent treatment options in oncology2005

Diagnosis and management of synovial sarcoma.

R Lor Randall, Kathryn L S Schabel, Ying Hitchcock, David E Joyner, Karen H Albritton

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current treatment options in oncology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Synovial sarcoma of the spine: a case involving paraspinal muscle with extensive calcification and the surgical consideration in treatment.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2014
    Review
  4. Article
  5. Giant subcutaneous synovial sarcoma: an interesting case.Journal of clinical and diagnostic research : JCDR · 2013
    Article
  6. Laryngeal synovial sarcoma: a rare clinical entity.Case reports in otolaryngology · 2013
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

R Lor RandallSarcoma Services, Suite 4260, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112, USA. r.lor.randall@lsc.utah.edu
Kathryn L S Schabel
Ying Hitchcock
David E Joyner
Karen H Albritton
Huntsman Cancer Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synovial sarcoma is a unique tumor with substantial promise for biologically targeted therapy. Although it demonstrates moderate chemosensitivity, with approximately 50% response rates to ifosfamide- and doxorubicin-containing regimens, it has a diagnostic translocation and a potentially informative chimeric protein product. Although surgical management remains the cornerstone to effect local control, therapeutic advancements are unlikely to occur by continuing to include advanced cases of synovial sarcomas in trials with other soft tissue sarcomas. Rather, attention should be turned toward prospective molecular targets and development of novel agents to exploit them. Research should be directed at understanding the fusion protein of the X,18 translocation and further validating the role of overexpressed proteins in synovial sarcoma. Meanwhile, carefully designed clinical trials of these agents, with translational correlates, will provide in vivo data to complement the preclinical experience.

Indexed as

Sarcoma, SynovialAdolescentAdultAntineoplastic AgentsBiomarkers, TumorCombined Modality TherapyDoxorubicinHumansIfosfamideOncogene Proteins, FusionPrognosisRadiotherapyTranslocation, GeneticAntineoplastic AgentsBiomarkers, TumorDoxorubicinIfosfamideOncogene Proteins, FusionSYT-SSX fusion protein

Identifiers

PMID16242050
OpenAlexW2014997217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.