ArticleMolekuliarnaia biologiia
[Down-regulation of TRIP6 expression induces actin cytoskeleton rearrangements in human carcinoma cell lines].
Article in Molekuliarnaia biologiia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- TRIM55 Promotes Proliferation of Hepatocellular Carcinoma Through Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling.Journal of hepatocellular carcinoma · 2023Article
- The LIM domain protein nTRIP6 modulates the dynamics of myogenic differentiation.Scientific reports · 2021Article
- TRIP6 is required for tension at adherens junctions.Journal of cell science · 2021Article
- TRIP6 enhances stemness property of breast cancer cells through activation of Wnt/β-catenin.Cancer cell international · 2020Article
- DNA methylation analysis of negative pressure therapy effect in diabetic foot ulcers.Endocrine connections · 2019Article
- TRIP6 functions as a potential oncogene and facilitated proliferation and metastasis of gastric cancer.Biologics : targets & therapy · 2019Article
- CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.Molecular & cellular proteomics : MCP · 2018Article
- The LIM domain protein nTRIP6 acts as a co-repressor for the transcription factor MEF2C in myoblasts.Scientific reports · 2016Article
- Overexpression of TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance (CAM-DR) via regulating nuclear p27(Kip1) expression in non-Hodgkin's lymphoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Characterization of TRIP6-dependent nasopharyngeal cancer cell migration.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Simultaneous analysis of distinct Omics data sets with integration of biological knowledge: Multiple Factor Analysis approach.BMC genomics · 2009Article
- Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Supervillin modulation of focal adhesions involving TRIP6/ZRP-1.The Journal of cell biology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Structure and dynamics of actin cytoskeleton play a role ih regulation of cell adhesion, spreading and migration. TRIP6 is a LIM domain-containing protein interacting with many actin-associated proteins and in addition modulating activity of certain transcription factors. To study functions of TRIP6 we inhibited its expression in A549 and A431 cells by short interfering RNAs (siRNAs). The TRIP6 knock-down lead to the increased number and length of stress fibers and to the induction of locomotive phenotype. There was observed decreased number and reorganization of focal adhesions revealed by staining for paxillin, and loss of cell to cell adhesions revealed by staining for E-cadherin. The above changes in cell morphology were accompanied by 2-fold increase in the cell motility rate assessed by the wound healing assay. Thus, down-regulation of TRIP6 in the cell lines used results in increase in the features characteristic to malignant transformation of epithelial cells. Possible mechanisms for the observed effects are discussed.
Indexed as
Identifiers
16240724PMC2773822W2070508820What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.