ReviewMental retardation and developmental disabilities research reviews2005
Advanced microscopic imaging methods to investigate cortical development and the etiology of mental retardation.
Review in Mental retardation and developmental disabilities research reviews, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Down Syndrome iPSC-Derived Astrocytes Impair Neuronal Synaptogenesis and the mTOR Pathway In Vitro.Molecular neurobiology · 2018Article
- Trisomy 21 and early brain development.Trends in neurosciences · 2012Review
- Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations.Cell death & disease · 2010Article
- Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome.Nature neuroscience · 2010Article
- Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Prenatal diagnosis of transient abnormal myelopoiesis in a Down syndrome fetus.Korean journal of radiologyArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Studies on human patients and animal models of disease have shown that disruptions in prenatal and early postnatal brain development are a root cause of mental retardation. Since proper brain development is achieved by a strict spatiotemporal control of neurogenesis, cell migration, and patterning of synapses, abnormalities in one or more of these events during prenatal development can lead to cognitive dysfunction after birth. Many of underlying causes of mental retardation must therefore be studied in developing brains. To aid in this research, live imaging using laser scanning microscopy (LSM) has recently allowed neuroscientists to delve deeply into the complex three-dimensional environment of the living brain to record dynamic cellular events over time. This review will highlight recent examples of how LSM is being applied to elucidate both normal and abnormal cortical development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.