Trial reportDigestive diseases and sciences2005
Inverse dose effect of pretest dietary lactose intake on breath hydrogen results and symptoms in lactase nonpersistent subjects.
Trial report in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00775567 (Colonic Microbial and Clinical Adaptation to Large Doses of Fructose), which is not on this map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Colonic Microbial and Clinical Adaptation to Large Doses of Fructose
Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- There may be a differential mechanistic impact on colorectal cancer of lactose-containing foods between lactase persistent and lactase non-persistent populations.Frontiers in nutrition · 2026Review
- Lactose Intolerance, Dairy Avoidance, and Treatment Options.Nutrients · 2018Review
- Adult lactose digestion status and effects on disease.Canadian journal of gastroenterology & hepatology · 2015Review
- Differential impact of lactose/lactase phenotype on colonic microflora.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2010Article
- Lack of effect of lactose digestion status on baseline fecal micoflora.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2009Article
- The molecular basis of lactose intolerance.Science progress · 2009Review
- Fructose malabsorption may be gender dependent and fails to show compensation by colonic adaptation.Digestive diseases and sciences · 2007Article
- The molecular basis of lactose intolerance.Science progress · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine a relationship between pretest intake of lactose and outcome of lactose breath hydrogen test. Patients presented at a testing laboratory participated in the study. A 3-hour breath hydrogen, 50-g lactose challenge was carried out. Results were tabulated and patients completed a 3-day recall diet questionnaire. Daily lactose intake was independently calculated and was associated with breath hydrogen and total symptom score. Statistical analysis used Spearman's correlation, Mann-Whitney U-test and chi2 or Fisher exact test. Of 118 patients, 50% were lactose maldigesters. In these patients, measured breath hydrogen and symptom scores were significantly higher in the lowest intake group (< 5 g/d) than in the highest intake group (> 20 g/d) (P < .05). In the presumed lactose digesters, 59% experienced some symptoms during testing for unclear reasons. Pretest dietary intake of lactose inversely affects results of breath hydrogen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.