ArticleMolecular imaging and biology
Circadian regulation of a viral gene promoter in live transgenic mice expressing firefly luciferase.
Article in Molecular imaging and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Using bioluminescence to image gene expression and spontaneous behavior in freely moving mice.PloS one · 2023Article
- Are the Patterns of Cytomegalovirus Viral Load Seen After Solid Organ Transplantation Affected by Circadian Rhythm?The Journal of infectious diseases · 2022Article
- Interplay between circadian clock and viral infection.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Continual conscious bioluminescent imaging in freely moving somatotransgenic mice.Scientific reports · 2017Article
- Varicella zoster virus vaccines: potential complications and possible improvements.Virologica Sinica · 2014Review
- Mutual antagonism between circadian protein period 2 and hepatitis C virus replication in hepatocytes.PloS one · 2013Article
- Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice.Molecular cancer therapeutics · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeThis study was conducted to test for possible circadian control of viral infection in live animals using bioluminescence imaging of a firefly luciferase transgene.
methodsTransgenic mice expressing the firefly luciferase gene under the control of the promoter and enhancer of the human cytomegalovirus major immediate-early gene (CMV::luc) were examined through whole-animal imaging. Mice were crossed with HRS/J hairless albino mice to improve imaging of deep structures.
resultsTransgene expression in the extremities and head was elevated around dusk in mice maintained in cycles of light and dark. Signal was also elevated during the animal's night in mice maintained in extended darkness. The viral promoter was induced during the active phase of the circadian locomotor rhythm in several tissues. Both the acinar cells and islets expressed the transgene in dissociated pancreas cultures.
conclusionsThese results suggest that viruses may exploit the circadian system for optimal timing of infection at particular phases in several tissue types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.