ArticleCirculation research2005
Embryonic even skipped-dependent muscle and heart cell fates are required for normal adult activity, heart function, and lifespan.
Article in Circulation research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- In Vivo Models of Cardiovascular Disease:Biomedicines · 2025Review
- Single-cell profiling of the developing embryonic heart in Drosophila.Development (Cambridge, England) · 2023Article
- A mosaic of conserved and novel modes of gene expression and morphogenesis in mesoderm and muscle formation of a larval bivalve.Organisms, diversity & evolution · 2022Article
- Review
- Distinct subsets of Eve-positive pericardial cells stabilise cardiac outflow and contribute to Hox gene-triggered heart morphogenesis inDevelopment (Cambridge, England) · 2018Article
- CF2 transcription factor is involved in the regulation of Mef2 RNA levels, nuclei number and muscle fiber size.PloS one · 2017Article
- SPARC-Dependent Cardiomyopathy in Drosophila.Circulation. Cardiovascular genetics · 2016Article
- Imaging Approaches to Investigate Myonuclear Positioning in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2016Article
- ROS regulate cardiac function via a distinct paracrine mechanism.Cell reports · 2014Article
- 3D chromatin interactions organize Yan chromatin occupancy and repression at the even-skipped locus.Genes & development · 2013Article
- Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification.Development (Cambridge, England) · 2012Article
- Drosophila models of cardiac disease.Progress in molecular biology and translational science · 2011Review
- Article
- Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand.Circulation research · 2010Article
- Multi-step control of muscle diversity by Hox proteins in the Drosophila embryo.Development (Cambridge, England) · 2010Article
- Non-autonomous modulation of heart rhythm, contractility and morphology in adult fruit flies.Developmental biology · 2009Article
- Cardiac gene regulatory networks in Drosophila.Biochimica et biophysica acta · 2009Review
- Defective decapentaplegic signaling results in heart overgrowth and reduced cardiac output in Drosophila.Genetics · 2007Article
- Functional conservation of zinc-finger homeodomain gene zfh1/SIP1 in Drosophila heart development.Development genes and evolution · 2006Article
- Bithorax complex genes control alary muscle patterning along the cardiac tube of Drosophila.Mechanisms of developmentArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The Drosophila pair-rule gene even skipped (eve) is required for embryonic segmentation and later in specific cell lineages in both the nervous system and the mesoderm. We previously generated eve mesoderm-specific mutants by combining an eve null mutant with a rescuing transgene that includes the entire locus, but with the mesodermal enhancer removed. This allowed us to analyze in detail the defects that result from a precisely targeted elimination of mesodermal eve expression in the context of an otherwise normal embryo. Absence of mesodermal eve causes a highly selective loss of the entire eve-expressing lineage in this germ layer, including those progeny that do not continue to express eve, suggesting that mesodermal eve precursor specification is not implemented. Despite the resulting absence of a subset of muscles and pericardial cells, mesoderm-specific eve mutants survive to fertile adulthood, providing an opportunity to examine the effects of these developmental abnormalities on adult fitness and heart function. We find that in these mutants, flying ability, myocardial performance under normal and stressed conditions, and lifespan are severely reduced. These data imply a nonautonomous role of the affected pericardial cells and body wall muscles in developing and/or maintaining cardiac performance and possibly other functions contributing to normal lifespan. Given the similarities of molecular-genetic control between Drosophila and vertebrates, these findings suggest that peri/epicardial influences may well be important for proper myocardial function.
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Registered trials
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