ArticleInfection and immunity2005
Regulation of RANTES promoter activation in gastric epithelial cells infected with Helicobacter pylori.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Interleukin-19 enhances eosinophil infiltration through upregulation of epithelium-derived RANTES expression via the ERK/NF-κB signalling pathway in patients with eosinophilic CRSwNP.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Immune Biology and Persistence of Helicobacter pylori in Gastric Diseases.Current topics in microbiology and immunology · 2023Article
- Lactobacillus paracasei strain 06TCa19 suppresses inflammatory chemokine induced by Helicobacter pylori in human gastric epithelial cells.Human cell · 2017Article
- A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma.PloS one · 2016Article
- Helicobacter pylori outer membrane vesicle proteins induce human eosinophil degranulation via a β2 Integrin CD11/CD18- and ICAM-1-dependent mechanism.Mediators of inflammation · 2015Article
- Outer membrane inflammatory protein A, a new virulence factor involved in the pathogenesis of Helicobacter pylori.Molecular biology reports · 2014Article
- Helicobacter pylori virulence and cancer pathogenesis.Future oncology (London, England) · 2014Review
- The combination of an oxygen-dependent degradation domain-regulated adenovirus expressing the chemokine RANTES/CCL5 and NK-92 cells exerts enhanced antitumor activity in hepatocellular carcinoma.Oncology reports · 2013Article
- Helicobacter pylori-associated regulation of forkhead transcription factors FoxO1/3a in human gastric cells.Helicobacter · 2012Article
- Paxillin is a novel cellular target for converging Helicobacter pylori-induced cellular signaling.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Article
- Host transcription factors in the immediate pro-inflammatory response to the parasitic mite Psoroptes ovis.PloS one · 2011Article
- Helicobacter pylori: gastric cancer and beyond.Nature reviews. Cancer · 2010Review
- Helicobacter pylori activate epidermal growth factor receptor- and phosphatidylinositol 3-OH kinase-dependent Akt and glycogen synthase kinase 3beta phosphorylation.Cellular microbiology · 2009Article
- OipA plays a role in Helicobacter pylori-induced focal adhesion kinase activation and cytoskeletal re-organization.Cellular microbiology · 2008Article
- Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors.Cancer research · 2008Article
- Regulation of IL-18 in Helicobacter pylori infection.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and TFF3 mRNAs in human gastric carcinoma cells.Scandinavian journal of gastroenterology · 2008Article
- Geographic differences in gastric cancer incidence can be explained by differences between Helicobacter pylori strains.Internal medicine (Tokyo, Japan) · 2008Review
- Helicobacter pylori environmental interactions: effect of acidic conditions on H. pylori-induced gastric mucosal interleukin-8 production.Cellular microbiology · 2007Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
RANTES, a CC chemokine, plays an important role in the inflammatory response associated with Helicobacter pylori infection. However, the mechanism by which H. pylori induces RANTES expression in the gastric mucosa is unknown. We cocultured gastric epithelial cells with wild-type H. pylori, isogenic oipA mutants, cag pathogenicity island (PAI) mutants, or double knockout mutants. Reverse transcriptase PCR showed that RANTES mRNA was induced by H. pylori and that the expression was both OipA and cag PAI dependent. Luciferase reporter gene assays and electrophoretic mobility shift assays showed that maximal H. pylori-induced RANTES gene transcription required the presence of the interferon-stimulated responsive element (ISRE), the cyclic AMP-responsive element (CRE), nuclear factor-interleukin 6 (NF-IL-6), and two NF-kappaB sites. OipA- and cag PAI-dependent pathways included NF-kappaB-->NF-kappaB/NF-IL-6/ISRE pathways, and cag PAI-dependent pathways additionally included Jun N-terminal kinase-->CRE/NF-kappaB pathways. The OipA-dependent pathways additionally included p38-->CRE/ISRE pathways. We confirmed the in vitro effects in vivo by examining RANTES mRNA levels in biopsy specimens from human gastric antral mucosa. RANTES mRNA levels in the antral mucosa were significantly higher for patients infected with cag PAI/OipA-positive H. pylori than for those infected with cag PAI/OipA-negative H. pylori or uninfected patients. The mucosal inflammatory response to H. pylori infection involves different signaling pathways for activation of the RANTES promoter, with both OipA and the cag PAI being required for full activation of the RANTES promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.