ArticleInfection and immunity2005
Studies of fibronectin-binding proteins of Streptococcus equi.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Geographic diversity of theFrontiers in veterinary science · 2025Article
- Conservation of vaccine antigen sequences encoded by sequenced strains of Streptococcus equi subsp. equi.Equine veterinary journal · 2023Article
- Comparative Genomic Analysis ofFrontiers in microbiology · 2021Article
- Identification of genes required for the fitness ofMicrobial genomics · 2020Article
- Pathogenicity Factors in Group C and G Streptococci.Microbiology spectrum · 2019Review
- Genetics and Pathogenicity Factors of Group C and G Streptococci.Microbiology spectrum · 2019Review
- Collagen-like proteins of pathogenic streptococci.Molecular microbiology · 2017Review
- Bivalent ligation of the collagen-binding modules of fibronectin by SFS, a non-anchored bacterial protein of Streptococcus equi.The Journal of biological chemistry · 2015Article
- Propolis modulates fibronectin expression in the matrix of thermal injury.BioMed research international · 2014Article
- Article
- Proteome variation among Filifactor alocis strains.Proteomics · 2012Article
- Getting to grips with strangles: an effective multi-component recombinant vaccine for the protection of horses from Streptococcus equi infection.PLoS pathogens · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus equi subsp. equi is the causative agent of strangles, a disease of the upper respiratory tract in horses. The initiation of S. equi subsp. equi infection is likely to involve cell surface-anchored molecules mediating bacterial adhesion to the epithelium of the host. The present study describes the cloning and characterization of FNEB, a fibronectin-binding protein with cell wall-anchoring motifs. FNEB can thus be predicted as cell surface located, contrary to the two previously characterized fibronectin-binding proteins in S. equi subsp. equi, FNE and SFS. Assays of antibody titers in horses and in experimentally infected mice indicate that the protein is immunogenic and expressed in vivo during S. equi subsp. equi infection. Using Western ligand blotting, it was shown that FNEB binds to the N-terminal 29-kDa fragment of fibronectin, while SFS and FNE both bind to the adjacent 40-kDa fragment. S. equi subsp. equi is known to bind fibronectin to a much lower degree than the closely related S. equi subsp. zooepidemicus, but the binding is primarily directed to the 29-kDa fragment. Inhibition studies using S. equi subsp. equi cells indicate that FNEB mediates cellular binding to fibronectin in this species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.