ArticleInfection and immunity2005
CD4+-T-cell responses generated during murine Salmonella enterica serovar Typhimurium infection are directed towards multiple epitopes within the natural antigen FliC.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Vaccine-induced inflammation and inflammatory monocytes promote CD4+ T cell-dependent immunity against murine salmonellosis.PLoS pathogens · 2023Article
- Heightened Virulence ofInfection and immunity · 2021Article
- CD4+ T cell immunity to Salmonella is transient in the circulation.PLoS pathogens · 2021Article
- A multi-epitope plant-made chimeric protein (LTBentero) targeting common enteric pathogens is immunogenic in mice.Plant molecular biology · 2020Article
- The Boosting Potential of Bacteria in Cancer Immunotherapy.Trends in molecular medicine · 2017Article
- Two NovelFrontiers in cellular and infection microbiology · 2017Article
- Chicken egg yolk antibodies (IgY) modulate the intestinal mucosal immune response in a mouse model of Salmonella typhimurium infection.International immunopharmacology · 2016Article
- Functional Activity of Antibodies Directed towards Flagellin Proteins of Non-Typhoidal Salmonella.PloS one · 2016Article
- The O-Antigen Capsule of Salmonella enterica Serovar Typhimurium Facilitates Serum Resistance and Surface Expression of FliC.Infection and immunity · 2015Article
- Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine.Vaccine · 2015Article
- Sequence- and Structure-Based Immunoreactive Epitope Discovery for Burkholderia pseudomallei Flagellin.PLoS neglected tropical diseases · 2015Article
- CD4+ T cell epitopes of FliC conserved between strains of Burkholderia: implications for vaccines against melioidosis and cepacia complex in cystic fibrosis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- A scalable method for biochemical purification of Salmonella flagellin.Protein expression and purification · 2014Article
- Immunity to intestinal pathogens: lessons learned from Salmonella.Immunological reviews · 2014Review
- Vaccination with a single CD4 T cell peptide epitope from a Salmonella type III-secreted effector protein provides protection against lethal infection.Infection and immunity · 2014Article
- Flagellin induces antibody responses through a TLR5- and inflammasome-independent pathway.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The Subtleties and Contrasts of the LeuO Regulator in Salmonella Typhi: Implications in the Immune Response.Frontiers in immunology · 2014Review
- CD103-CD11b+ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin.Mucosal immunology · 2014Article
- Recombinant Salmonella enterica serovar Typhimurium as a vaccine vector for HIV-1 Gag.Viruses · 2013Review
- Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development.PLoS pathogens · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The flagellar filament protein FliC is a natural antigen recognized by memory CD4+ T cells recovered from Salmonella enterica serovar Typhimurium-infected humans and mice. To further investigate T-cell responses to FliC, we derived FliC-specific CD4+-T-cell clones from mice of two different haplotypes following oral S. enterica serovar Typhimurium infection. Using C-terminal truncations of MalE-FliC recombinant fusion proteins, we mapped antigenic activity to four different regions of FliC; three of the four epitope-containing regions were present in both FliC and the alternate flagellin subunit FljB. We determined that two novel FliC epitopes were also present in flagellins from several gram-negative enteric bacterial species: E(k)-restricted FliC 80-94 (amino acids 80 to 94) and A(b)-restricted FliC 455-469. Further mapping confirmed the presence of two previously identified FliC epitopes: A(k)-restricted FliC 339-350 and A(b)-restricted FliC 428-442. Therefore, like the recognition site of the innate immune receptor Toll-like receptor 5, three of four FliC epitopes recognized by CD4+ T cells colocalize in the D0/D1 domains of FliC. Salmonella-infected macrophages and dendritic cells stimulated epitope-specific CD4+-T-cell proliferation; infected dendritic cells also activated T cells to produce gamma interferon. These data demonstrate that Salmonella infection generates murine CD4+-T-cell responses to multiple epitopes in the natural antigen FliC and that recognition of infected phagocytes by FliC-specific CD4+ T cells triggers effector functions known to be essential for protective immunity. Together, these data suggest that FliC-specific CD4+ T cells may contribute to cell-mediated host defenses against Salmonella.
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