ReviewThe Journal of physiology2006
Origin of spontaneous rhythmicity in smooth muscle.
Review in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
- Cytoskeletal prestress homeostasis is a biological principle that governs living cell structure and function.Mechanobiology in medicine · 2026Review
- Orai storeoperated CaChannels (Austin, Tex.) · 2025Review
- Mechanical Modulation, Physiological Roles, and Imaging Innovations of Intercellular Calcium Waves in Living Systems.Cancers · 2025Review
- Article
- Involvement of NO/cGMP Signaling Pathway, CaInternational journal of molecular sciences · 2022Article
- Regulation ofiScience · 2022Article
- Pattern Formation in a Spatially Extended Model of Pacemaker Dynamics in Smooth Muscle Cells.Bulletin of mathematical biology · 2022Article
- Erectile Dysfunction: Key Role of Cavernous Smooth Muscle Cells.Frontiers in pharmacology · 2022Review
- Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice.Communications biology · 2021Article
- Mediators of human ureteral smooth muscle contraction-a role for erythropoietin, tamsulosin and Gli effectors.Translational andrology and urology · 2021Article
- BK Channels Are Activated by Functional Coupling With L-Type CaFrontiers in insect science · 2021Article
- A Novel in situ Approach to Studying Detrusor Smooth Muscle Cells in Mice.Scientific reports · 2020Article
- Article
- The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat.Frontiers in physiology · 2015Review
- The role of cellular coupling in the spontaneous generation of electrical activity in uterine tissue.PloS one · 2015Article
- Tissue-engineered lymphatic graft for the treatment of lymphedema.The Journal of surgical research · 2014Review
- Calcium signalling in Cajal-like interstitial cells of the lower urinary tract.Nature reviews. Urology · 2014Review
- In vitro effect of isotocin on ovarian tunica albuginea contractility of gilthead seabream (Sparus aurata L.) in different reproductive conditions.Fish physiology and biochemistry · 2014Article
- The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.Nature medicine · 2014Article
- Ovarian contractility in reared gilthead seabream (Sparus aurata L.) in different phases of the reproductive cycle.Fish physiology and biochemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhythmic electrical activity is a feature of most smooth muscles but the mechanical consequences can vary from regular rapid phasic contractions to sustained contracture. For many years it was thought that spontaneous electrical activity originated in smooth muscle cells but recently it has become apparent that there are specialized pacemaker cells in many organs that are morphologically and functionally distinct from smooth muscle and that the former cells are the source of spontaneous electrical activity. Such a pacemaker function is well documented for the ICC of the gastrointestinal tract but evidence is accumulating that ICC-like cells play a similar role in other types of smooth muscle. We have recently shown that there are specialized pacemaking cells in the rabbit urethra which are spontaneously active when freshly isolated, readily distinguishable from smooth muscle cells under bright field illumination and relatively easy to study using patch-clamp and confocal imaging techniques. Recent results suggest that calcium oscillations in isolated rabbit urethral interstitial cells are initiated by calcium release from ryanodine sensitive intracellular stores, that oscillation frequency is very sensitive to the external calcium concentration and that conversion of the primary oscillation to a propagated calcium wave depends upon IP3-induced calcium release.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.