ReviewThe Journal of physiology2006
Lipid rafts, the sarcoplasmic reticulum and uterine calcium signalling: an integrated approach.
Review in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 72 citations in OpenAlex.
- Cholesterol and PIPAdvances in experimental medicine and biology · 2023Article
- Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders.Antioxidants (Basel, Switzerland) · 2021Review
- Gestational and Hormonal Effects on Magnesium Sulfate's Ability to Inhibit Mouse Uterine Contractility.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Liver X Receptors: A Possible Link between Lipid Disorders and Female Infertility.International journal of molecular sciences · 2018Review
- A computational model of excitation and contraction in uterine myocytes from the pregnant rat.Scientific reports · 2018Article
- Gestation changes sodium pump isoform expression, leading to changes in ouabain sensitivity, contractility, and intracellular calcium in rat uterus.Physiological reports · 2017Article
- Parturition dysfunction in obesity: time to target the pathobiology.Reproductive biology and endocrinology : RB&E · 2015Review
- Effect of high-fat diet on rat myometrium during pregnancy-isolated myometrial mitochondria are not affected.Pflugers Archiv : European journal of physiology · 2015Article
- Maternal age effects on myometrial expression of contractile proteins, uterine gene expression, and contractile activity during labor in the rat.Physiological reports · 2015Article
- Atherosclerosis differentially affects calcium signalling in endothelial cells from aortic arch and thoracic aorta in Apolipoprotein E knockout mice.Physiological reports · 2014Article
- Elevated maternal lipids in early pregnancy are not associated with risk of intrapartum caesarean in overweight and obese nulliparous women.BMC pregnancy and childbirth · 2013Article
- What do we know about what happens to myometrial function as women age?Journal of muscle research and cell motility · 2012Article
- Article
- Ca2+ clearance and contractility in vascular smooth muscle: evidence from gene-altered murine models.Journal of molecular and cellular cardiology · 2008Review
- The molecular basis of tolerance.Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2008Review
- CB2 receptors in reproduction.British journal of pharmacology · 2008Review
- Regulation of the uterine contractile apparatus and cytoskeleton.Seminars in cell & developmental biology · 2007Review
- Depletion of membrane cholesterol eliminates the Ca2+-activated component of outward potassium current and decreases membrane capacitance in rat uterine myocytes.The Journal of physiology · 2007Article
- Ions in smooth muscle, now and then.The Journal of physiology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathways involved in Ca2+ signalling in the uterus remain incompletely understood, impairing our ability to prevent preterm and difficult labours. In this review we focus on two elements in the pathway of Ca2+ signalling that have recently emerged as playing important roles: membrane lipid rafts and the sarcoplasmic reticulum. We examine the evidence for lipid rafts in the uterus and discuss their functional role. We suggest that the increases in cytosolic [Ca2+] and contractility that occur with raft disruption are due, at least in part, to effects on large conductance Ca2+-activated K+ (BK) channels that are localized to rafts. The role of the SR in contributing to subsarcolemmal cytosolic microdomains in uterus is evaluated, along with its interactions with ion channels on the plasma membrane. Thus, signalling microdomains play an important, but incompletely understood, role in the uterus, and integrating them into other Ca2+ signalling pathways is a challenge for further research. We suggest that the role of the SR changes in pregnancy, from promoting quiescence via BK channels or SR Ca2+ uptake, to promoting Ca2+ entry and contractility at term, and relate data on lipid rafts to clinical outcome in obese pregnant women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.