ArticleDiabetologia2005
Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle.
Article in Diabetologia, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 77 citations in OpenAlex.
- A Critical Assessment of Fasting to Promote Metabolic Health and Longevity.Endocrine reviews · 2025Review
- Feeding beta adrenergic agonists alters mitochondria metabolism in porcine skeletal muscle.Journal of animal science · 2025Article
- Impact of Roux-en-Y Gastric Bypass on Mitochondrial Biogenesis and Dynamics in Leukocytes of Obese Women.Antioxidants (Basel, Switzerland) · 2022Article
- How Does Ginsenoside Rh2 Mitigate Adipogenesis in Cultured Cells and Obese Mice?Molecules (Basel, Switzerland) · 2020Article
- Association of breast cancer risk and the mTOR pathway in women of African ancestry in 'The Root' Consortium.Carcinogenesis · 2017Article
- PGC-1Physiological reports · 2017Article
- Functional characterization of AMP-activated protein kinase signaling in tumorigenesis.Biochimica et biophysica acta · 2016Review
- Lipid Use and Misuse by the Heart.Circulation research · 2016Review
- Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity.Nutrition & metabolism · 2016Review
- Maintenance of skeletal muscle energy homeostasis during prolonged wintertime fasting in the raccoon dog (Nyctereutes procyonoides).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Article
- Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome.Journal of lipids · 2015Review
- A splice mutation in the PHKG1 gene causes high glycogen content and low meat quality in pig skeletal muscle.PLoS genetics · 2014Article
- Exercise-induced skeletal muscle remodeling and metabolic adaptation: redox signaling and role of autophagy.Antioxidants & redox signaling · 2014Review
- Cardiac lipotoxicity: molecular pathways and therapeutic implications.Current heart failure reports · 2013Review
- Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction.Regulatory peptides · 2012Article
- PPARbeta activation induces rapid changes of both AMPK subunit expression and AMPK activation in mouse skeletal muscle.Molecular endocrinology (Baltimore, Md.) · 2011Article
- The aging stress response.Molecular cell · 2010Review
- AMPK enhances the expression of pancreatic duodenal homeobox-1 via PPARalpha, but not PPARgamma, in rat insulinoma cell line INS-1.Acta pharmacologica Sinica · 2010Article
- Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.Cell metabolism · 2010Article
- Leptin prevents the metabolic effects of adiponectin in L6 myotubes.Diabetologia · 2009Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisAMP-activated protein kinase (AMPK) regulates metabolic adaptations in skeletal muscle. The aim of this study was to investigate whether AMPK modulates the expression of skeletal muscle genes that have been implicated in lipid and glucose metabolism under fed or fasting conditions.
methodsTwo genetically modified animal models were used: AMPK gamma3 subunit knockout mice (Prkag3(-/-)) and skeletal muscle-specific transgenic mice (Tg-Prkag3(225Q)) that express a mutant (R225Q) gamma3 subunit. Levels of mRNA transcripts of genes involved in lipid and glucose metabolism in white gastrocnemius muscles of these mice (under fed or 16-h fasting conditions) were assessed by quantitative real-time PCR.
resultsWild-type mice displayed a coordinated increase in the transcription of skeletal muscle genes encoding proteins involved in lipid/oxidative metabolism (lipoprotein lipase, fatty acid transporter, carnitine palmitoyl transferase-1 and citrate synthase) and glucose metabolism (glycogen synthase and lactate dehydrogenase) in response to fasting. In contrast, these fasting-induced responses were impaired in Prkag3(-/-) mice. The transcription of genes involved in lipid and oxidative metabolism was increased in the skeletal muscle of Tg-Prkag3(225Q) mice compared with that in wild-type mice. Moreover, the expression of the genes encoding hexokinase II and 6-phosphofrucktokinase was decreased in Tg-Prkag3(225Q) mice after fasting. CONCLUSIONS/
interpretationAMPK is involved in the coordinated transcription of genes critical for lipid and glucose metabolism in white glycolytic skeletal muscle.
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