ArticleThe Journal of molecular diagnostics : JMD2005
Tumor microsatellite instability in early onset gastric cancer.
Article in The Journal of molecular diagnostics : JMD, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 65 citations in OpenAlex.
- Early onset gastric cancer: clinical and molecular insights into a rising epidemic among younger adults.Proceedings (Baylor University. Medical Center) · 2025Article
- Nomogram models for predicting overall and cancer-specific survival in early-onset gastric cancer patients: a population-based cohort study.American journal of cancer research · 2024Article
- Low incidence of microsatellite instability in gastric cancers and its association with the clinicopathological characteristics: a comparative study.Scientific reports · 2023Article
- Heterogeneity and Adjuvant Therapeutic Approaches in MSI-H/dMMR Resectable Gastric Cancer: Emerging Trends in Immunotherapy.Annals of surgical oncology · 2023Review
- Article
- The clinicopathological characteristics of early-onset gastric cancer and its evolutionary trends: a retrospective study.American journal of cancer research · 2022Article
- Comparative investigation of early-onset gastric cancer.Oncology letters · 2021Review
- Finding the hot spot: identifying immune sensitive gastrointestinal tumors.Translational gastroenterology and hepatology · 2020Review
- Different Incidence of Early-Onset Gastric Carcinoma Depending on Ethnicity: Preliminary Results of a Hospital in Liangshan.TheScientificWorldJournal · 2020Article
- Article
- The effects of BRCA1 expression on the chemosensitivity of gastric cancer cells to platinum agents.Oncology letters · 2019Article
- Microsatellite Instability and Altered Expressions of MLH1 and MSH2 in Gastric CancerAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Article
- The prognostic value of age in non-metastatic gastric cancer after gastrectomy: a retrospective study in the U.S. and China.Journal of Cancer · 2018Article
- Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for Standardization.Applied immunohistochemistry & molecular morphology : AIMM · 2017Article
- Molecular alterations in gastric cancer with special reference to the early-onset subtype.World journal of gastroenterology · 2016Review
- Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer.Gastroenterology · 2015Article
- Effect of MLH1 -93G>A on gene expression in patients with colorectal cancer.Medical oncology (Northwood, London, England) · 2014Article
- Promoter methylation and immunohistochemical expression of hMLH1 and hMSH2 in sporadic colorectal cancer: a study from India.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Molecular and survival differences between familial and sporadic gastric cancers.BioMed research international · 2013Article
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer (GC) remains a leading cause of cancer mortality worldwide. Genetic factors are implicated, including DNA mismatch repair (MMR) deficiency manifested as tumor microsatellite instability (MSI). However, a standardized panel of markers and a definition of low-versus-high level MSI in GC are lacking. We examined a population-based cohort of early onset (<or=50 yrs) gastric cancer. We identified 211 cases of early onset gastric cancer in Central-East Ontario from 1989 to 1993, with archival material available for 139 cases. Testing included a six-mononucleotide marker panel and a three-MMR immunohistochemical panel. Overall, 30% (41 of 139) of GC were MSI+, with allelic shifts at one to eight markers. An unexpected discordance between the BAT-25, BAT-26, and BAT-40 markers was observed in the MSI+ cases. Six cases showing multiple loci instability (>or=3 markers MSI+/MSI-high) demonstrated MMR protein deficiency. Three novel hMLH1 mutations (two germline frameshift and one somatic nonsense) were also found. The only significant clinicopathological associations were increased tumor size in MSI+ cases (P=0.04) and Lauren histotype (P=0.006) and tumor grade (P=0.007) in MSI-high cases. Tumor size, location, depth, nodal status, and Ming subtype were significant prognostic variables. Therefore, we propose a new definition of high-level MSI based on unifying characteristics of instability of more than or equal to three of six mononucleotide markers and loss of MMR protein expression.
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