ReviewSchizophrenia bulletin2006
Emerging empirical evidence on the ethics of schizophrenia research.
Review in Schizophrenia bulletin, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Longitudinal consent-related abilities among research participants with schizophrenia: results from the CATIE study.Schizophrenia research · 2011Trial
- Multimedia Aided Consent for Alzheimer's Disease Research.Clinical gerontologistTrial
- Increasing participation of people with thought disorder in clinical research.European psychiatry : the journal of the Association of European Psychiatrists · 2026Review
- Obstacles, Opportunities, and Ethical Considerations for Genomic Investigations of Individuals Continuously Hospitalized with Treatment-resistant Schizophrenia.Schizophrenia bulletin open · 2025Article
- Influence of Dispositional Optimism on Ethically Salient Research Perspectives: A Pilot Study.Ethics & human research · 2022Article
- Perceived protectiveness of research safeguards and influences on willingness to participate in research: A novel MTurk pilot study.Journal of psychiatric research · 2021Article
- Do human subject safeguards matter to potential participants in psychiatric genetic research?Journal of psychiatric research · 2019Article
- Is It Ethical to Use Prognostic Estimates from Machine Learning to Treat Psychosis?AMA journal of ethics · 2018Article
- The Challenges of Using Self-Report Measures with People with Severe Mental Illness: Four Participants' Experiences of the Research Process.Community mental health journal · 2017Article
- The effect of depression on the decision to join a clinical trial.Journal of consulting and clinical psychology · 2017Article
- Are individuals living with mental illness and their preferred alternative decision-makers attuned and aligned in their attitudes regarding treatment decisions?Journal of psychiatric research · 2016Article
- Moral Stress and Job Burnout Among Frontline Staff Conducting Clinical Research on Affective and Anxiety Disorders.Professional psychology, research and practice · 2016Article
- Customising informed consent procedures for people with schizophrenia in India.Social psychiatry and psychiatric epidemiology · 2015Article
- Informed consent in the psychosis prodrome: ethical, procedural and cultural considerations.Philosophy, ethics, and humanities in medicine : PEHM · 2014Review
- Giving voice to study volunteers: comparing views of mentally ill, physically ill, and healthy protocol participants on ethical aspects of clinical research.Journal of psychiatric research · 2014Article
- Participants' Perceptions of Deep Brain Stimulation Research for Treatment-Resistant Depression: Risks, Benefits, and Therapeutic Misconception.AJOB primary research · 2011Article
- Screening for understanding of research in the inpatient psychiatry setting.Journal of empirical research on human research ethics : JERHRE · 2011Article
- Ethics in Psychiatric Research: A Review of 25 Years of NIH-funded Empirical Research Projects.AJOB primary research · 2011Article
- Capacity to make medical treatment decisions in multiple sclerosis: a potentially remediable deficit.Journal of clinical and experimental neuropsychology · 2010Article
- Worth the risk? Relationship of incentives to risk and benefit perceptions and willingness to participate in schizophrenia research.Schizophrenia bulletin · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Many challenging ethical questions come with the scientific efforts to understand the nature and treatment of schizophrenia. The empirical study of ethical aspects of schizophrenia research has sought to clarify and resolve many of these questions. In this article we provide an overview of the existing data-based literature on schizophrenia research ethics and outline directions for future inquiry. We examine 5 broad categories of inquiry into the ethics of schizophrenia research: (1) Scientific designs (eg, placebo-controlled studies and medication-free intervals, prodromal and high-risk research, and genetics research); (2) informed consent and decision-making capacity, including assessment of decisional abilities, as well as intervention studies; (3) understanding and perceptions of risk and benefit (including the therapeutic misconception); (4) influences on research participation (including voluntarism, altruism, and other motivations); and (5) key participant safeguards, such as protocol review and participant advocates. We discuss how empirical work in each of these areas answers certain questions and raises new ones. Finally, we highlight important gaps in our understanding of ethically relevant aspects of schizophrenia research and offer a specific research agenda for empirical ethics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.