ArticleJournal of bacteriology2005
Chlamydial GroEL autoregulates its own expression through direct interactions with the HrcA repressor protein.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Comparative transcriptomics reveals genes commonly induced by distinct stressors inInfection and immunity · 2026Article
- Comparative Transcriptomics Reveals Genes Commonly Induced by Distinct Stressors inbioRxiv : the preprint server for biology · 2025Article
- A lineage-specific heat-induced feedback loop controls HrcA to promote chlamydial fitness under stress.bioRxiv : the preprint server for biology · 2025Article
- A conservedMicrobiology (Reading, England) · 2025Article
- Insights into the Orchestration of Gene Transcription Regulators inInternational journal of molecular sciences · 2022Review
- Feeling the Heat: TheBiomolecules · 2021Article
- Robust Heat Shock Response inFrontiers in microbiology · 2021Article
- Protein aggregation in bacteria.FEMS microbiology reviews · 2020Review
- The Interplay between Two Transcriptional Repressors and Chaperones OrchestratesInternational journal of molecular sciences · 2018Review
- Biochemical and Genetic Analysis of the Chlamydia GroEL Chaperonins.Journal of bacteriology · 2017Article
- Article
- Following the Footsteps of Chlamydial Gene Regulation.Molecular biology and evolution · 2015Article
- Transcriptional regulation of the Chlamydia heat shock stress response in an intracellular infection.Molecular microbiology · 2015Article
- The early gene product EUO is a transcriptional repressor that selectively regulates promoters of Chlamydia late genes.Molecular microbiology · 2012Article
- Differential effects of DNA supercoiling on Chlamydia early promoters correlate with expression patterns in midcycle.Journal of bacteriology · 2012Article
- A Chlamydia-specific C-terminal region of the stress response regulator HrcA modulates its repressor activity.Journal of bacteriology · 2011Article
- Identification and functional analysis of CT069 as a novel transcriptional regulator in Chlamydia.Journal of bacteriology · 2011Article
- Transcriptional regulation of stress response and motility functions in Helicobacter pylori is mediated by HspR and HrcA.Journal of bacteriology · 2007Article
- Chlamydial Hsp60-2 is iron responsive in Chlamydia trachomatis serovar E-infected human endometrial epithelial cells in vitro.Infection and immunity · 2007Article
- Chlamydial type III secretion system is encoded on ten operons preceded by sigma 70-like promoter elements.Journal of bacteriology · 2007Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
In the pathogenic bacterium Chlamydia trachomatis, a transcriptional repressor, HrcA, regulates the major heat shock operons, dnaK and groE. Cellular stress causes a transient increase in transcription of these heat shock operons through relief of HrcA-mediated repression, but the pathway leading to derepression is unclear. Elevated temperature alone is not sufficient, and it is hypothesized that additional chlamydial factors play a role. We used DNA affinity chromatography to purify proteins that interact with HrcA in vivo and identified a higher-order complex consisting of HrcA, GroEL, and GroES. This endogenous HrcA complex migrated differently than recombinant HrcA, but the complex could be disrupted, releasing native HrcA that resembled recombinant HrcA. In in vitro assays, GroEL increased the ability of HrcA to bind to the CIRCE operator and to repress transcription. Other chlamydial heat shock proteins, including the two additional GroEL paralogs present in all chlamydial species, did not modulate HrcA activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.