ArticleJournal of medical genetics2006
Phenotype of triploid embryos.
Article in Journal of medical genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Distribution of diandric and digynic triploidy depending on gestational age.Journal of assisted reproduction and genetics · 2021Trial
- PGT-A reveals triploid embryos among normally fertilized oocytes: frequency and blastocyst features.Journal of assisted reproduction and genetics · 2026Article
- Maternal age and genome-wide failure of meiotic recombination are associated with triploid conceptions in humans.American journal of human genetics · 2025Article
- Accurate identification of abnormal ploidy using an artificial intelligence model in preimplantation genetic testing.Human reproduction open · 2025Article
- The Identification of Molecular Ploidy Status of Abnormal Pronuclear Zygotes Reveals a Significant Number of Euploid Blastocysts Available for Conception.Biomedicines · 2024Article
- Naturally occurring horse model of miscarriage reveals temporal relationship between chromosomal aberration type and point of lethality.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Generation, genomic characterization, and differentiation of triploid human embryonic stem cells.Stem cell reports · 2023Article
- Prenatal Diagnosis of Triploidy in Fetus with Unexpected Chromosomal Translocation of Maternal Origin.International journal of molecular and cellular medicine · 2023Article
- Optical Genome Mapping in Routine Human Genetic Diagnostics-Its Advantages and Limitations.Genes · 2021Article
- Genotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Review
- When embryology meets genetics: the definition of developmentally incompetent preimplantation embryos (DIPE)-the consensus of two Italian scientific societies.Journal of assisted reproduction and genetics · 2021Article
- The significance of the placental genome and methylome in fetal and maternal health.Human genetics · 2020Review
- ETV2-null porcine embryos survive to post-implantation following incomplete enucleation.Reproduction (Cambridge, England) · 2020Article
- Low-pass genome sequencing versus chromosomal microarray analysis: implementation in prenatal diagnosis.Genetics in medicine : official journal of the American College of Medical Genetics · 2020Article
- Loss of Ikbkap/Elp1 in mouse oocytes causes spindle disorganization, developmental defects in preimplantation embryos and impaired female fertility.Scientific reports · 2019Article
- Screening of triploid with low-coverage whole-genome sequencing by a single-nucleotide polymorphism-based test in miscarriage tissue.Journal of assisted reproduction and genetics · 2019Article
- Likelihood ratio formulae for disputed parentage when the product of conception is trisomic.International journal of legal medicine · 2017Article
- Genetic Counseling and Prenatal Diagnosis of Triploidy During the Second Trimester of Pregnancy.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2017Article
- Article
- Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors.Genome research · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenotypes of triploid fetuses and placentae are now well established and known to correlate with parental origin of the extra haploid set of chromosomes. In fetuses, it is not clear whether there is a direct parent of origin effect on the fetus itself or if the phenotypes are the result of growth differences influenced by abnormalities in growth and function of the placenta. Examining the phenotype of triploid embryos at an earlier stage in gestation, when the placenta effects may be less pronounced, could help clarify this question. A phenotype characteristic of triploidy in the embryonic period has been described; however, parental origin was not determined in these embryonic cases. In the present study, a population of triploid embryos is assessed to determine if there is a correlation between parental origin and phenotype. Parental origin was determined in 27 first trimester miscarriages. Digyny accounted for 19 cases and diandry for eight cases. Assessment of embryonic phenotype with parental origin showed no correlation between the phenotype of the embryo and parental origin of the extra haploid set. While there may be subtle effects of imprinting on embryonic development, they are not as obvious as they are in the mouse, consistent with the general trend of fewer imprinted genes in human beings compared with the mouse.
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