ArticleRespiratory research2005
Psoriasin, one of several new proteins identified in nasal lavage fluid from allergic and non-allergic individuals using 2-dimensional gel electrophoresis and mass spectrometry.
Article in Respiratory research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 54 citations in OpenAlex.
- A novel biological interpretation of neuropsychiatric symptoms in patients with allergic rhinitis: insights from brain functional connectivity gradient and serum multi-omics analysis.BMC medical imaging · 2026Article
- Multi-omics in Allergic Rhinitis: Mechanism Dissection and Precision Medicine.Clinical reviews in allergy & immunology · 2025Review
- The Role of WNT3A Protein and Gene Variants in Allergic Rhinitis: A Case-Control Study.Current issues in molecular biology · 2024Article
- [Application of proteomics in allergic rhinitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Review
- Nasal mucus proteome and its involvement in allergic rhinitis.Expert review of proteomics · 2020Article
- Differential expression and role of S100 proteins in chronic rhinosinusitis.Current opinion in allergy and clinical immunology · 2020Review
- Rapid Detection and Identification of Antimicrobial Peptide Fingerprints of Nasal Fluid by Mesoporous Silica Particles and MALDI-TOF/TOF Mass Spectrometry: From the Analytical Approach to the Diagnostic Applicability in Precision Medicine.International journal of molecular sciences · 2018Article
- Untargeted analysis of the airway proteomes of children with respiratory infections using mass spectrometry based proteomics.Scientific reports · 2018Article
- Calgranulin C (S100A12) Is Differentially Expressed in Subtypes of Chronic Rhinosinusitis.American journal of rhinology & allergy · 2018Observational
- Plasma proteins as potential targets of abnormal Savda syndrome in asthma patients treated with unique Uighur prescription.Experimental and therapeutic medicine · 2017Article
- Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis.Annual review of pathology · 2017Review
- Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options.GMS current topics in otorhinolaryngology, head and neck surgery · 2015Review
- Damage-associated molecular patterns and their receptors in upper airway pathologies.Cellular and molecular life sciences : CMLS · 2013Review
- S100A7 enhances invasion of human breast cancer MDA-MB-468 cells through activation of nuclear factor-κB signaling.World journal of surgical oncology · 2013Article
- Diminished levels of nasal S100A7 (psoriasin) in seasonal allergic rhinitis: an effect mediated by Th2 cytokines.Respiratory research · 2012Article
- S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection.BMC pulmonary medicine · 2011Article
- Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis.The Journal of allergy and clinical immunology · 2010Article
- Identification of five candidate lung cancer biomarkers by proteomics analysis of conditioned media of four lung cancer cell lines.Molecular & cellular proteomics : MCP · 2009Article
- Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis.The Journal of allergy and clinical immunology · 2009Review
- Epithelium, inflammation, and immunity in the upper airways of humans: studies in chronic rhinosinusitis.Proceedings of the American Thoracic Society · 2009Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtravasation and luminal entry of plasma occurs continuously in the nose. This process is markedly facilitated in patients with symptomatic allergic rhinitis, resulting in an increased secretion of proteins. Identification of these proteins is an important step in the understanding of the pathological mechanisms in allergic diseases. DNA microarrays have recently made it possible to compare mRNA profiles of lavage fluids from healthy and diseased patients, whereas information on the protein level is still lacking.
methodsNasal lavage fluid was collected from 11 patients with symptomatic allergic rhinitis and 11 healthy volunteers. 2-dimensional gel electrophoresis was used to separate proteins in the lavage fluids. Protein spots were picked from the gels and identified using mass spectrometry and database search. Selected proteins were confirmed with western blot.
results61 spots were identified, of which 21 were separate proteins. 6 of these proteins (psoriasin, galectin-3, alpha enolase, intersectin-2, Wnt-2B and hypothetical protein MGC33648) had not previously been described in nasal lavage fluids. The levels of psoriasin were markedly down-regulated in allergic individuals. Prolactin-inducible protein was also found to be down-regulated, whereas different fragments of albumin together with Ig gamma 2 chain c region, transthyretin and splice isoform 1 of Wnt-2B were up-regulated among the allergic patients.
conclusionThe identification of proteins in nasal lavage fluid with 2-dimensional gelelectrophoresis in combination with mass spectrometry is a novel tool to profile protein expression in allergic rhinitis and it might prove useful in the hunt for new therapeutic targets or diagnostic markers for allergic diseases. Psoriasin is a potent chemotactic factor and its down-regulation during inflammation might be of importance for the outcome of the disease.
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