ArticleImmunology2005
Induction of antigen-specific regulatory T cells in the liver-draining celiac lymph node following oral antigen administration.
Article in Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Identification and characterization of dietary antigens in oral tolerance.Science immunology · 2026Article
- Exploring the Role of GITR/GITRL Signaling: From Liver Disease to Hepatocellular Carcinoma.Cancers · 2024Review
- Tolerogenic Immunomodulation by PEGylated Antigenic Peptides.Frontiers in immunology · 2020Article
- Downregulation of L-arginine metabolism in dendritic cells induces tolerance to exogenous antigen.International journal of immunopathology and pharmacology · 2017Article
- A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice.Nature communications · 2016Article
- The Role of Lymphatic Endothelial Cells in Liver Injury and Tumor Development.Frontiers in immunology · 2016Review
- Dynamics of antigen presentation to transgene product-specific CD4Molecular therapy. Methods & clinical development · 2016Article
- Perihepatic nodes detected by point-of-care ultrasound in acute hepatitis and acute-on-chronic liver disease.World journal of gastroenterology · 2015Article
- Article
- Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.The Journal of clinical investigation · 2013Article
- Characterization of the liver-draining lymph nodes in mice and their role in mounting regional immunity to HBV.Cellular & molecular immunology · 2013Article
- Oral gene application using chitosan-DNA nanoparticles induces transferable tolerance.Clinical and vaccine immunology : CVI · 2012Article
- Oral tolerance.Immunological reviews · 2011Review
- How tolerogenic dendritic cells induce regulatory T cells.Advances in immunology · 2010Review
- Serum-derived exosomes from antigen-fed mice prevent allergic sensitization in a model of allergic asthma.Immunology · 2008Article
- Article
- Oral tolerance.Immunological reviews · 2005Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulatory T cells are induced by oral administration of an antigen, but the physiological requirements and localization of the inductive sites are largely unknown. Using an adoptive transfer system of cells transgenic for ovalbumin T-cell receptor (OVA TCR tg), we found that antigen-specific CD4+ T cells were activated in the liver-draining celiac lymph node (CLN) shortly after ovalbumin feeding, and that a significantly higher proportion of the T cells in the CLN developed into the putative regulatory phenotype [co-expressing CD25 with the glucocortico-induced tumour necrosis factor (TNF) receptor family related gene (GITR), cytotoxic T-lymphocyte antigen (CTLA)-4 and CD103] than in Peyer's patches, the mesenteric and peripheral lymph nodes and the spleen. In addition, a particularly high level of expression of CD103 on the OVA-specific T cells in the CLN may favour homing to the epithelium of the intestine. While equally suppressive, OVA tg T cells isolated from the CLN of OVA-fed DO11.10 mice were less dependent on transforming growth factor (TGF)-beta for suppression than cells isolated from the peripheral and mesenteric lymph nodes, which indicates the involvement of an additional suppressive mechanism. The expression of FoxP3 was not up-regulated in any of the lymph node compartments studied. Our phenotypic and functional findings suggest that the induction of regulatory T cells in the CLN may be relevant in the control of the immune response to dietary antigens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.