ArticleBritish journal of clinical pharmacology2005
General practitioners' adoption of new drugs and previous prescribing of drugs belonging to the same therapeutic class: a pharmacoepidemiological study.
Article in British journal of clinical pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Factors affecting the uptake of new medicines: a systematic literature review.BMC health services research · 2014Pooled it
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- Association between physician adoption of a new oral anti-diabetic medication and Medicare and Medicaid drug spending.BMC health services research · 2019Article
- Early National Dissemination of Abiraterone and Enzalutamide for Advanced Prostate Cancer in Medicare Part D.Journal of oncology practice · 2017Article
- Who Were the Early Adopters of Dabigatran?: An Application of Group-based Trajectory Models.Medical care · 2016Article
- In with the new: the determinants of prescribing innovation by general practitioners in Ireland.The European journal of health economics : HEPAC : health economics in prevention and care · 2012Article
- Primary care physicians' adoption of new drugs is not associated with their clinical interests: a pharmacoepidemiologic study.Scandinavian journal of primary health care · 2011Article
- The use of drugs is not as rational as we believe… but it can't be! The emotional roots of prescribing.European journal of clinical pharmacology · 2011Article
- Therapeutic traditions, patient socioeconomic characteristics and physicians' early new drug prescribing--a multilevel analysis of rosuvastatin prescription in south Sweden.European journal of clinical pharmacology · 2009Article
- Determinants of the range of drugs prescribed in general practice: a cross-sectional analysis.BMC health services research · 2007Article
- Prescribing statins.British journal of clinical pharmacology · 2005Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo test the hypothesis that general practitioners (GPs) with high prescribing levels of certain drugs will adopt new drugs belonging to the same therapeutic group faster than those with low prescribing levels.
methodsThe adoption of four new drugs: esomeprazol, selective cyclo-oxygenase-2 inhibitors, new triptans, and angiotensin-II receptor blockers were analysed using population-based prescription data. We used the preference proportion (prescriptions for new rather than older alternatives for the same indication) to measure GPs' adoption rate. Annual prescribing volume and prevalence were used to measure previous prescribing of older drug alternatives. We modelled the preference proportion using multiple linear regression analysis and the prescribing of older drugs as independent variables. We controlled for the GPs' general prescribing level and weighted for practice size. In the first three analyses, we dichotomized data using the median, lower and upper quartile as cut-off point. Next, we grouped data into quartiles and finally, we used continuous data.
resultsFor esomeprazol and new triptans there was a higher preference for new drugs among "high prescribers", but only when this term was defined as the upper quarter and the upper half of previous prescribing levels, respectively (mean difference in preference proportion: 10.2% (99% confidence interval = 1.3%, 19.1%) and 8.2% (0.2%, 16.2%)). For the remaining two drug classes the associations were weak and almost all statistically nonsignificant.
conclusionThere is no consistent association between GPs' level of drug prescribing and their adoption of new drugs of the same therapeutic group.
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