Trial reportBritish journal of clinical pharmacology2005
Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin.
Trial report in British journal of clinical pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 107 citations in OpenAlex.
- Almorexant effects on CYP3A4 activity studied by its simultaneous and time-separated administration with simvastatin and atorvastatin.European journal of clinical pharmacology · 2013Trial
- Trial
- Food-drug interactions of novel drugs used in cardiologic and diabetic patients - a PRISMA scoping review.Frontiers in pharmacology · 2026Review
- Dietary Modulation of CYP3A4 and Its Impact on Statins and Antidiabetic Drugs: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism.Archives of pharmacal research · 2024Article
- The Challenge and Importance of Integrating Drug-Nutrient-Genome Interactions in Personalized Cardiovascular Healthcare.Journal of personalized medicine · 2022Review
- In Vitro Assessment of Transporter Mediated Perpetrator DDIs for Several Hepatitis C Virus Direct-Acting Antiviral Drugs and Prediction of DDIs with Statins Using Static Models.The AAPS journal · 2022Article
- Pharmacogenomics and circadian rhythms as mediators of cardiovascular drug-drug interactions.Current research in pharmacology and drug discovery · 2021Review
- Article
- Physiologically-Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid-to-Lactone Conversion.CPT: pharmacometrics & systems pharmacology · 2019Article
- A regulatory science viewpoint on botanical-drug interactions.Journal of food and drug analysis · 2018Review
- ABT-737 and pictilisib synergistically enhance pitavastatin-induced apoptosis in ovarian cancer cells.Oncology letters · 2018Article
- Drug safety: The concept, inception and its importance in patients' health.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2016Review
- Grapefruit-medication interactions: forbidden fruit or avoidable consequences?CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2013Review
- Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.Pharmacology & therapeutics · 2012Review
- Elucidating the role of dose in the biopharmaceutics classification of drugs: the concepts of critical dose, effective in vivo solubility, and dose-dependent BCS.Pharmaceutical research · 2012Article
- Pitavastatin: a review of its use in the management of hypercholesterolaemia or mixed dyslipidaemia.Drugs · 2012Review
- The effect of grapefruit juice on drug disposition.Expert opinion on drug metabolism & toxicology · 2011Review
- Place of pitavastatin in the statin armamentarium: promising evidence for a role in diabetes mellitus.Drug design, development and therapy · 2011Review
- Grapefruit-drug interactions.Drugs · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo compare the effects of grapefruit juice (GFJ) on the pharmacokinetics of pitavastatin and atorvastatin.
methodsIn a randomized, four-phase crossover study, eight healthy subjects consumed either GFJ or water t.i.d. for 4 days in each trial. On each final day, a single dose of 4 mg pitavastatin or 20 mg atorvastatin was administered.
resultsGFJ increased the mean AUC(0-24) of atorvastatin acid by 83% (95% CI 23-144%) and that of pitavastatin acid by 13% (-3 to 29%).
conclusionsPitavastatin, unlike atorvastatin, appears to be scarcely affected by the CYP3A4-mediated metabolism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.