ArticleThe Journal of infectious diseases2005
Higher frequency of HIV-1-specific T cell immune responses in African American children vertically infected with HIV-1.
Article in The Journal of infectious diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Observational
- Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects.Journal of virology · 2011Article
- Immunodominance of HIV-1 specific CD8+ T-cell responses is related to disease progression rate in vertically infected adolescents.PloS one · 2011Article
- Decay kinetics of HIV-1 specific T cell responses in vertically HIV-1 exposed seronegative infants.Frontiers in immunology · 2011Article
- Enhancement of human antigen-specific memory T-cell responses by interleukin-7 may improve accuracy in diagnosing tuberculosis.Clinical and vaccine immunology : CVI · 2008Article
- Associations between the human MHC and sustained virologic response in the treatment of chronic hepatitis C virus infection.Genes and immunity · 2008Article
- Single-cell, phosphoepitope-specific analysis demonstrates cell type- and pathway-specific dysregulation of Jak/STAT and MAPK signaling associated with in vivo human immunodeficiency virus type 1 infection.Journal of virology · 2008Article
- The role of race and gender in T cell responses in children perinatally infected with HIV-1.The Journal of infectious diseases · 2005Article
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8 authors at 3 institutions in 2 countries.
Funding
Abstract
The progression of human immunodeficiency virus (HIV) disease and plasma levels of HIV may differ between racial groups. We compared HIV-specific T cell responses between vertically HIV-1-infected Hispanic and African American children. Subjects were matched for sex, age, viral load, and CD4(+) cell count in 18 pairs; T cell responses were measured by cytokine-enhanced interferon- gamma assay. Peripheral blood mononuclear cells were stimulated with HIV consensus peptides from Gag, Nef, and Tat. The influence of ethnicity, sex, age, viral load, and CD4(+) cell count on T cell responses was determined through linear regression analyses. After adjustment for CD4(+) count, age, and log(10) viral load, African American children demonstrated significantly higher Gag responses (average, 486 spot-forming cells higher; P=.01) than Hispanic children; this was significantly driven by robust responses in African American girls near the age of puberty, many of whom carried the human leukocyte antigen class I B*58 allele.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.