ArticleThe Journal of infectious diseases2005
Cytoplasmic inclusion bodies are detected by synthetic antibody in ciliated bronchial epithelium during acute Kawasaki disease.
Article in The Journal of infectious diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 99 citations in OpenAlex.
- Current Prognostic Models Fail to Reliably Distinguish Kawasaki Disease From Pediatric Multisystem Inflammatory Syndrome Temporally Associated With COVID-19.The Pediatric infectious disease journal · 2026Article
- Human pathological findings in Kawasaki disease: a narrative review of autopsy and biopsy evidence.Frontiers in immunology · 2026Review
- Potential Mechanisms and Hypotheses for Pathogenic Microorganisms Triggering Kawasaki Disease.Clinical reviews in allergy & immunology · 2025Review
- Monoclonal Antibodies From Children With Acute Kawasaki Disease Identify a Common Antigenic Target in Fatal Cases Over 5 Decades.Laboratory investigation; a journal of technical methods and pathology · 2025Article
- An Update on Kawasaki Disease.Current rheumatology reports · 2024Review
- The etiologies of Kawasaki disease.The Journal of clinical investigation · 2024Review
- Kawasaki disease and the environment: an enigmatic interplay.Frontiers in immunology · 2023Review
- Oblivion: autopsy findings of a 31-year-old man with sudden cardiac arrest, a case report of a sequalae of Kawasaki disease.Autopsy & case reports · 2022Article
- Kawasaki Disease and Pediatric Infectious Diseases During the Coronavirus Disease 2019 Pandemic.The Journal of pediatrics · 2021Article
- Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic.World journal of pediatrics : WJP · 2021Article
- Diagnosing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Related Multisystem Inflammatory Syndrome in Children (MIS-C): Focus on the Gastrointestinal Tract and the Myocardium.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management.Rheumatology international · 2021Review
- Kawasaki-like disease in children with COVID-19: A hypothesis.Medical hypotheses · 2020Article
- A Protein Epitope Targeted by the Antibody Response to Kawasaki Disease.The Journal of infectious diseases · 2020Article
- Antibodies and Immunity During Kawasaki Disease.Frontiers in cardiovascular medicine · 2020Review
- B Cells and Antibodies in Kawasaki Disease.International journal of molecular sciences · 2019Review
- The Gut Microbiota-Host Partnership as a Potential Driver of Kawasaki Syndrome.Frontiers in pediatrics · 2019Review
- Is Kawasaki disease an infectious disorder?International journal of rheumatic diseases · 2018Review
- The Epidemiology and Pathogenesis of Kawasaki Disease.Frontiers in pediatrics · 2018Review
- Kawasaki disease: a matter of innate immunity.Clinical and experimental immunology · 2016Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundIn developed nations, Kawasaki disease (KD) is the most common cause of acquired heart disease in children. An infectious etiology is likely but has not yet been identified. We have previously reported that oligoclonal immunoglobulin A plasma cells infiltrate acute KD tissues and that synthetic KD antibodies detect a distinctive spheroidal antigen in acute KD ciliated bronchial epithelium.
methodsTo further characterize the antigen in acute KD bronchi, we examined paraffin-embedded ciliated bronchial epithelium using light microscopy (LM) and transmission electron microscopy (TEM).
resultsThe spheroids observed by immunohistochemistry (IHC) are visualized as inclusion bodies with hematoxylin-eosin and nucleic acid stains and in methylene blue/azure II/basic fuchsin trichrome-stained plastic sections, suggesting the presence of both protein and nucleic acid. The structures visualized by LM correspond to homogeneous electron-dense perinuclear inclusion bodies (up to 1.4 microns in diameter) in ciliated bronchial epithelium from 4 patients with acute KD examined by TEM. Inclusion bodies were not present in control bronchial epithelium or in nonciliated cells.
conclusionsThe antigen detected in acute KD ciliated bronchial epithelium by IHC with synthetic KD antibodies resides in cytoplasmic inclusion bodies that are consistent with aggregates of viral proteins and associated nucleic acid and may derive from the etiologic agent of KD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.