ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2005
Isolation, X location and activity of the marsupial homologue of SLC16A2, an XIST-flanking gene in eutherian mammals.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolution.Genome research · 2012Article
- Does the human X contain a third evolutionary block? Origin of genes on human Xp11 and Xq28.Genome research · 2009Article
- Specific patterns of histone marks accompany X chromosome inactivation in a marsupial.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- Unravelling the evolutionary origins of X chromosome inactivation in mammals: insights from marsupials and monotremes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- The status of dosage compensation in the multiple X chromosomes of the platypus.PLoS genetics · 2008Article
- Origin and evolution of candidate mental retardation genes on the human X chromosome (MRX).BMC genomics · 2008Article
- Physical map of two tammar wallaby chromosomes: a strategy for mapping in non-model mammals.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Genes flanking Xist in mouse and human are separated on the X chromosome in American marsupials.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Article
- The region homologous to the X-chromosome inactivation centre has been disrupted in marsupial and monotreme mammals.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Article
- The search for a marsupial XIC reveals a break with vertebrate synteny.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
X chromosome inactivation (XCI) achieves dosage compensation between males and females for most X-linked genes in eutherian mammals. It is a whole-chromosome effect under the control of the XIST locus, although some genes escape inactivation. Marsupial XCI differs from the eutherian process, implying fundamental changes in the XCI mechanism during the evolution of the two lineages. There is no direct evidence for the existence of a marsupial XIST homologue. XCI has been studied for only a handful of genes in any marsupial, and none in the model kangaroo Macropus eugenii (the tammar wallaby). We have therefore studied the sequence, location and activity of a gene SLC16A2 (solute carrier, family 16, class A, member 2) that flanks XIST on the human and mouse X chromosomes. A BAC clone containing the marsupial SLC16A2 was mapped to the end of the long arm of the tammar X chromosome and used in RNA FISH experiments to determine whether one or both loci are transcribed in female cells. In male and female cells, only a single signal was found, indicating that the marsupial SLC16A2 gene is silenced on the inactivated X.
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