Evidence map›Paper›PMID 16235021›Full record

ArticleCurrent microbiology2005

The bcsA gene influences multiple aspects of development in Myxococcus xanthus.

John K Cusick, Ronald E Gill

Abstract read
PubMed Publisher
In one paragraph

Article in Current microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John K CusickDepartment of Microbiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA. john.cusick@uchsc.edu
Ronald E Gill

Funding

REGULATION OF GENE EXPRESSION BY CELL-CELL INTERACTIONSR01GM031900 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI GILL, RONALD E · 1985 to 1995
–
NIGMS NIH HHS GM31900
6 · The paper itself

Abstract

M. xanthus strains containing a mutation in the bcsA gene are able to bypass the B and C signaling requirements for development. The bcsA mutant was examined with regards to several aspects of development to better ascertain the function of the bcsA gene. The bcsA mutant developed on nutrient levels sufficient to support vegetative growth in wild-type cells, supporting previous evidence that the bcsA gene inhibits development. The earliest effect of the bcsA mutation on the development program was when cells were beginning to aggregate together to form fruiting bodies. Spores produced by bcsA mutants were hypersusceptible to sodium dodecyl sulfate, suggesting that the bcsA gene is important for optimal spore production. Transcription of the bcsA gene was induced significantly during development at a time when cells were beginning to aggregate together. Collectively, these results indicate that the bcsA gene inhibits development and is also transcriptionally upregulated during development.

Indexed as

Genes, BacterialAnti-Bacterial Agentsbeta-GalactosidaseCell AdhesionGene FusionGenes, ReporterMorphogenesisMyxococcus xanthusSodium Dodecyl SulfateSpores, BacterialTranscription, GeneticAnti-Bacterial Agentsbeta-GalactosidaseSodium Dodecyl Sulfate

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.