ArticleJournal of controlled release : official journal of the Controlled Release Society2005
ATP-loaded liposomes effectively protect mechanical functions of the myocardium from global ischemia in an isolated rat heart model.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Programming the beating heart with polymer catalysis: a therapeutic microenvironment revolution.Journal of nanobiotechnology · 2026Review
- BMAL1 in Ischemic Heart Disease: A Narrative Review from Molecular Clock to Myocardial Pathology.International journal of molecular sciences · 2025Review
- Engineered ATP-Loaded Extracellular Vesicles Derived from Mesenchymal Stromal Cells: A Novel Strategy to Counteract Cell ATP Depletion in an In Vitro Model.International journal of molecular sciences · 2025Article
- Review
- Hyperbaric oxygen therapy in the ATLS/ACLS resuscitative management of acutely ill or severely injured patients with severe anemia: a review.Frontiers in medicine · 2024Review
- Liposome-Tethered Gold Nanoparticles Triggered by Pulsed NIR Light for Rapid Liposome Contents Release and Endosome Escape.Pharmaceutics · 2022Review
- Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer.Molecular oncology · 2020Article
- Near Infrared-Triggered Liposome Cages for Rapid, Localized Small Molecule Delivery.Scientific reports · 2020Article
- The interstitium in cardiac repair: role of the immune-stromal cell interplay.Nature reviews. Cardiology · 2018Review
- Size-Dependent Ability of Liposomes to Accumulate in the Ischemic Myocardium and Protect the Heart.Journal of cardiovascular pharmacology · 2018Article
- Advanced targeted nanomedicine.Journal of biotechnology · 2015Article
- Maintenance of ischemic β cell viability through delivery of lipids and ATP by targeted liposomes.Biomaterials science · 2014Article
- Angiogenic therapy for cardiac repair based on protein delivery systems.Heart failure reviews · 2012Review
- Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells.Cancer research · 2012Article
- Liposomes in diagnosis and treatment of cardiovascular disorders.Methodist DeBakey cardiovascular journal · 2012Review
- Liposome-delivered ATP effectively protects the retina against ischemia-reperfusion injury.Molecular vision · 2010Article
- Targeting ischemic penumbra: part I - from pathophysiology to therapeutic strategy.Journal of experimental stroke & translational medicine · 2010Article
- Protective effect of coenzyme Q10-loaded liposomes on the myocardium in rabbits with an acute experimental myocardial infarction.Pharmaceutical research · 2007Article
- ATP-loaded liposomes effectively protect the myocardium in rabbits with an acute experimental myocardial infarction.Pharmaceutical research · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
ATP-loaded liposomes (ATP-L) infused into Langendorff-instrumented isolated rat hearts protect the mechanical functions of the myocardium during ischemia/reperfusion. The left ventricular developed pressure (LVDP) at the end of the reperfusion in the ATP-L group recovered to 72% of the baseline (preservation of the systolic function) compared to 26%, 40%, and 51% in the groups treated with Krebs-Henseleit (KH) buffer, empty liposomes (EL), and free ATP (F-ATP), respectively. The ATP-L-treated group also showed a significantly lower left ventricular end diastolic pressure (LVEDP; better preservation of the diastolic function) after ischemia/reperfusion than controls. After incubating the F-ATP and ATP-L with ATPase, the protective effect of the F-ATP was completely eliminated because of ATP degradation, while the protective effect of the ATP-L remained unchanged. Fluorescence microscopy confirmed the accumulation of liposomes in ischemic areas, and the net ATP in the ischemic heart increased with ATP-L. Our results suggest that ATP-L can effectively protect myocardium from ischemic/reperfusion damage.
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Registered trials
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