Evidence map›Paper›PMID 16231970›Full record

Trial reportPLoS medicine2005

Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial.

Bertran Auvert, Dirk Taljaard, Emmanuel Lagarde, Joëlle Sobngwi-Tambekou, Rémi Sitta, Adrian Puren

Erratum issued 8 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PLoS medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 8 registered trials, which are not on this map. Cited by 1,063 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,063citing papers in PubMed, 11 pooled it
107.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00122525 phase3terminatednot on this map

Effect of Safe Male Circumcision on Incidence of Infection by HIV, HSV-2 and of Genital Ulceration

TypeinterventionalSponsorFrench National Agency for Research on AIDS and Viral HepatitisRan2002 to 2005Enrolled3,274ConditionsHIV Infections, Herpes Genitalis, Venereal DiseasesArmsMale Circumcision
NCT01757938 nacompletednot on this mapstarted 2011, after this paper: background citation

Shang Ring Versus Forceps-guided Adult Male Circumcision: a Randomized Controlled Effectiveness Study in Southwestern Uganda.

TypeinterventionalSponsorMbarara University of Science and TechnologyRan2011 to 2011Enrolled138ConditionsHIVArmsShang Ring Guided Circumcision, Forceps Guided Circumcision
NCT02277795 nacompletednot on this mapstarted 2015, after this paper: background citation

Evaluation of the AccuCirc for Early Infant Male Circumcision in Nyanza, Kenya

TypeinterventionalSponsorBrigham and Women's HospitalRan2015 to 2016Enrolled704ConditionsMale CircumcisionArmsAccuCirc
NCT02337179 nacompletednot on this mapstarted 2011, after this paper: background citation

A Pilot Study to Introduce Male Circumcision (MC) Services to Prevent HIV Infection in Two High Prevalence Areas of the Dominican Republic (DR)

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2011 to 2017Enrolled539ConditionsCircumcision, Male, HIV, AIDSArmsVoluntary medical male circumcision
NCT02497989 nacompletednot on this mapstarted 2015, after this paper: background citation

Male Circumcision for HIV Prevention in Kenya: Seeking Effective Strategies to Recruit Older Men

TypeinterventionalSponsorImpact Research & Development OrganizationRan2015 to 2016Enrolled2,785ConditionsHIV/AIDSArmsInter-personal Communication (IPC), Dedicated Service Outlets (DSO)
NCT03338699 nacompletednot on this mapstarted 2018, after this paper: background citation

Evaluation of the ShangRing vs. Mogen Clamp for Early Infant Male Circumcision (EIMC) in Sub-Saharan Africa

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2018 to 2020Enrolled1,380ConditionsCircumcisionArmsShangRing, Mogen clamp
NCT03412071 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Testing the Ability of a Microbiome - Focused Intervention to Reduce HIV Susceptibility in Ugandan Men

TypeinterventionalSponsorUniversity of TorontoRan2017 to 2019Enrolled125ConditionsForeskin HIV SusceptibilityArmsOral Tinidazole, Topical metronidazole, Topical Clindamycin, Topical Hydrogen Peroxide
NCT06273696 completednot on this mapstarted 2019, after this paper: background citation

Evaluation of the Acceptability and Safety of the ShangRing Device for Male Circumcision in Shinyanga, Tanzania

Typeobservational_patient_registrySponsorIntraHealth InternationalRan2019 to 2019Enrolled575ConditionsPenile Infection, Penile Haematoma, Penile Bleeding, DeformityArmsShangRing
3 · Its place in the literature

Who cites it

1,063 citing papers in PubMed, 11 syntheses or guidelines pooled it, 2,445 citations in OpenAlex.

  1. Circumcision for HIV Prevention in Men Who Have Sex With Men: An Updated Meta-Analysis.Journal of acquired immune deficiency syndromes (1999) · 2026
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  5. Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
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1,003 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bertran AuvertHôpital Ambroise-Paré, Assitance Publique-Hôpitaux de Paris, Boulogne, France. bertran.auvert@apr.aphp.fr
Dirk Taljaard
Emmanuel Lagarde
Joëlle Sobngwi-Tambekou
Rémi Sitta
Adrian Puren
Inserm · FRNational Institute for Communicable Diseases

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObservational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled intervention trial was conducted in a general population of South Africa to test this hypothesis. METHODS AND

findingsA total of 3,274 uncircumcised men, aged 18-24 y, were randomized to a control or an intervention group with follow-up visits at months 3, 12, and 21. Male circumcision was offered to the intervention group immediately after randomization and to the control group at the end of the follow-up. The grouped censored data were analyzed in intention-to-treat, univariate and multivariate, analyses, using piecewise exponential, proportional hazards models. Rate ratios (RR) of HIV incidence were determined with 95% CI. Protection against HIV infection was calculated as 1 - RR. The trial was stopped at the interim analysis, and the mean (interquartile range) follow-up was 18.1 mo (13.0-21.0) when the data were analyzed. There were 20 HIV infections (incidence rate = 0.85 per 100 person-years) in the intervention group and 49 (2.1 per 100 person-years) in the control group, corresponding to an RR of 0.40 (95% CI: 0.24%-0.68%; p < 0.001). This RR corresponds to a protection of 60% (95% CI: 32%-76%). When controlling for behavioural factors, including sexual behaviour that increased slightly in the intervention group, condom use, and health-seeking behaviour, the protection was of 61% (95% CI: 34%-77%).

conclusionMale circumcision provides a degree of protection against acquiring HIV infection, equivalent to what a vaccine of high efficacy would have achieved. Male circumcision may provide an important way of reducing the spread of HIV infection in sub-Saharan Africa. (Preliminary and partial results were presented at the International AIDS Society 2005 Conference, on 26 July 2005, in Rio de Janeiro, Brazil.).

Indexed as

Circumcision, MaleHealth BehaviorSexual BehaviorAdolescentAdultCondomsHIV-1HIV InfectionsHumansMaleSouth AfricaTreatment OutcomeUrban Population

Identifiers

PMID16231970
PMCPMC1262556
OpenAlexW2115373328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.