ArticleHistochemistry and cell biology2006
Replication of centromeric heterochromatin in mouse fibroblasts takes place in early, middle, and late S phase.
Article in Histochemistry and cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Developmental differences in genome replication program and origin activation.Nucleic acids research · 2020Article
- Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair.Nucleus (Austin, Tex.) · 2019Article
- Next-Generation Sequencing Enables Spatiotemporal Resolution of Human Centromere Replication Timing.Genes · 2019Article
- Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.Nucleic acids research · 2017Article
- Internal modifications in the CENP-A nucleosome modulate centromeric dynamics.Epigenetics & chromatin · 2017Article
- Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N.Genes & development · 2015Article
- Assessing cell cycle progression of neural stem and progenitor cells in the mouse developing brain after genotoxic stress.Journal of visualized experiments : JoVE · 2014Article
- Article
- Homologous chromosomes make contact at the sites of double-strand breaks in genes in somatic G0/G1-phase human cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Functional centromeres determine the activation time of pericentric origins of DNA replication in Saccharomyces cerevisiae.PLoS genetics · 2012Article
- Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin.Nucleic acids research · 2012Article
- Dynamics of CENP-N kinetochore binding during the cell cycle.Journal of cell science · 2011Article
- Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase.PLoS genetics · 2010Article
- Position of human chromosomes is conserved in mouse nuclei indicating a species-independent mechanism for maintaining genome organization.Chromosoma · 2008Article
- Dynamics of inner kinetochore assembly and maintenance in living cells.The Journal of cell biology · 2008Article
- Recent progress in histochemistry.Histochemistry and cell biology · 2007Review
- Localization of proteasomes and proteasomal proteolysis in the mammalian interphase cell nucleus by systematic application of immunocytochemistry.Histochemistry and cell biology · 2007Article
- The histochemistry and cell biology vade mecum: a review of 2005-2006.Histochemistry and cell biology · 2006Review
- Uncoupling global and fine-tuning replication timing determinants for mouse pericentric heterochromatin.The Journal of cell biology · 2006Article
- [Regulation of DNA replication timing].Molekuliarnaia biologiiaReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The replication of eukaryotic chromosomes takes place throughout S phase, but little is known how this process is organized in space and time. Early and late replicating chromosomal domains appear to localize to distinct spatial compartments of the nucleus where DNA synthesis can take place at defined times during S phase. In general, transcriptionally active chromatin replicates early in S phase whereas transcriptionally inactive chromatin replicates later. Here we provide evidence for significant deviation from this dogma in mouse NIH3T3 cells. While the bulk pericentromeric heterochromatin replicates exclusively during mid to late S phase, centromeric DNA domains associated with constitutive kinetochore proteins are replicated throughout all stages of S phase. On an average, 12+/-4% of centromeres replicate in early S phase. Early replication of a subset of centromeres was also detected in living C2C12 murine cells. Thus, in contrast to expectation, late replication is not an obligatory feature of centromeric heterochromatin in murine cells and it does not determine their 'heterochromatic state'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.