ArticlePsychopharmacology2005
5-HT(1A) and 5-HT(2A) receptors in the rat dorsal periaqueductal gray mediate the antipanic-like effect induced by the stimulation of serotonergic neurons in the dorsal raphe nucleus.
Article in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 74 citations in OpenAlex.
- A systematic investigation of the differential roles for ventral tegmentum serotonin 1- and 2-type receptors on food intake in the rat.Brain research · 2016Article
- The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic.Neuroscience and biobehavioral reviews · 2014Review
- Sex differences in anxiety and emotional behavior.Pflugers Archiv : European journal of physiology · 2013Review
- Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats.Psychopharmacology · 2013Article
- A role for 5-HT1A receptors in the basolateral amygdala in the development of conditioned defeat in Syrian hamsters.Pharmacology, biochemistry, and behavior · 2012Article
- Differential effects of social defeat in rats with high and low locomotor response to novelty.Neuroscience · 2011Article
- Involvement of dorsal raphe nucleus and dorsal periaqueductal gray 5-HT receptors in the modulation of mouse defensive behaviors.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2011Article
- The serotonin releaser fenfluramine alters the auditory responses of inferior colliculus neurons.Hearing research · 2007Article
- The pharmacology of the neurochemical transmission in the midbrain raphe nuclei of the rat.Current neuropharmacology · 2006Article
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2 authors at 1 institution in 1 country.
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Abstract
rationaleIt has been proposed that the serotonergic pathway that connects the dorsal raphe nucleus (DRN) to the dorsal periaqueductal gray (DPAG) is implicated in the regulation of escape, a behavior that has been related to panic.
objectivesWe further evaluated this hypothesis by investigating whether intra-DRN injection of the 5-HT(1A) receptor antagonist WAY-100635 changes the escape response of rats submitted to the elevated T-maze. This test also measures inhibitory avoidance, which has been associated with generalized anxiety disorder. We also investigated whether the 5-HT(1A) and 5-HT(2A) receptors in the DPAG mediate the behavioral consequences induced by the injection of WAY-100635 into the DRN.
resultsIntra-DRN injection of WAY-100635 facilitated inhibitory avoidance, while impairing escape. The same effect was obtained after intra-DRN injection of the glutamate receptor agonist kainic acid. Preadministration of WAY-100635 into the DPAG counteracted the effect induced by intra-DRN injection of WAY-100635 and of kainic acid on escape, but not on inhibitory avoidance. Preadministration of the preferential 5-HT(2A) receptor antagonist ketanserin into the DPAG abolished the effects of intra-DRN injection of WAY-100635 on both elevated T-maze tasks.
conclusionThe results are indicative that 5-HT(1A) autoreceptors in the DRN are under tonic inhibitory influence by endogenous 5-HT. The effects of 5-HT release in the DPAG after intra-DRN injection of WAY-100635 and kainic acid on inhibitory avoidance and escape involve different 5-HT receptor subtypes. Whereas 5-HT(2A) receptors in the DPAG seem to mediate the effect of 5-HT on both behaviors, 5-HT(1A) receptors are only involved in the regulation of escape.
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