ReviewGene therapy2005
HSV-1-based amplicon vectors: design and applications.
Review in Gene therapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- An HSV-1-H129 amplicon tracer system for rapid and efficient monosynaptic anterograde neural circuit tracing.Nature communications · 2022Article
- Chemogenetics: Beyond Lesions and Electrodes.Neurosurgery · 2021Review
- Improvement of HSV-1 based amplicon vectors for a safe and long-lasting gene therapy in non-replicating cells.Molecular therapy. Methods & clinical development · 2021Article
- Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous System.Diseases (Basel, Switzerland) · 2018Review
- Intravesical treatment of advanced urothelial bladder cancers with oncolytic HSV-1 co-regulated by differentially expressed microRNAs.Gene therapy · 2016Article
- Silencing Status Epilepticus-Induced BDNF Expression with Herpes Simplex Virus Type-1 Based Amplicon Vectors.PloS one · 2016Article
- Elevation of intraocular pressure in rodents using viral vectors targeting the trabecular meshwork.Experimental eye research · 2015Review
- Methods for gene transfer to the central nervous system.Advances in genetics · 2014Review
- Virally mediated gene manipulation in the adult CNS.Frontiers in molecular neuroscience · 2011Article
- Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells).Cell biology and toxicology · 2010Article
- Design and application of oncolytic HSV vectors for glioblastoma therapy.Expert review of neurotherapeutics · 2009Review
- Cardiovascular gene therapy: current status and therapeutic potential.British journal of pharmacology · 2007Review
- Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag.Vaccine · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amplicons are defective, helper-dependent herpes simplex virus type 1 (HSV-1)-based vectors able to convey more than 100 kbp of foreign DNA to the nucleus of mammalian cells. This unique feature make amplicons very appealing for preventive or therapeutic gene transfer requiring the transduction of very large pieces of DNA, as well as for upstream fundamental studies, such as functional genomics. Several recent achievements in amplicon technology have allowed to produce relatively large amounts of essentially helper-free amplicons, as well as to expand the host range of these vectors. In this review, we will update the current know-how concerning design, construction, and recent applications, as well as the potential and current limitations, of this interesting and promising class of vectors.
Indexed as
Identifiers
16231049What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.