ArticleEndocrine2005
Silent myocardial ischemia is associated with autonomic neuropathy and other cardiovascular risk factors in type 1 and type 2 diabetic subjects, especially in those with microalbuminuria.
Article in Endocrine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Identification of Silent Myocardial Ischemia in Patients with Long-Term Type 1 and Type 2 Diabetes.International journal of environmental research and public health · 2022Article
- Occult Perforated Gangrenous Gallbladder Found on Magnetic Resonance Cholangiopancreatography.Cureus · 2021Article
- Admission ECG changes predict short term-mortality after acute myocardial infarction less reliable in patients with diabetes.Scientific reports · 2021Article
- Gangrenous cholecystitis: A silent but potential fatal disease in patients with diabetic neuropathy. A case report.World journal of clinical cases · 2018Article
- Atypical presentation of acute and chronic coronary artery disease in diabetics.World journal of cardiology · 2014Review
- Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength?World journal of diabetes · 2014 · on this mapReview
- Cardiac autonomic neuropathy in patients with diabetes mellitus.World journal of diabetes · 2014 · on this mapReview
- The prevalence, characteristics, and clinical significance of abnormal albuminuria in patients with hypertension.Scientific reports · 2014Article
- Microalbuminuria in untreated prehypertension and hypertension without diabetes.International journal of clinical and experimental medicine · 2014Article
- Article
- The prevalence and characteristics of microalbuminuria in the general population: a cross-sectional study.BMC research notes · 2013Article
- Article
- Silent myocardial infarction in women with type II diabetes mellitus and microalbuminuria.Therapeutics and clinical risk management · 2008Article
- The association of diabetes and older age with the absence of chest pain during acute coronary syndromes.Western journal of nursing research · 2008Article
- Symptoms across the continuum of acute coronary syndromes: differences between women and men.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2008Article
- Silent myocardial ischemia: Current perspectives and future directions.Experimental and clinical cardiology · 2007Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The prevalence of silent myocardial ischemia (SMI) seems to be above average in diabetic subjects. As routine screening is costly, identifying high-risk populations is mandatory. This study aimed to estimate the prevalence of SMI in diabetic subjects and in controls and to define the diabetic population at risk. We studied 353 asymptomatic caucasian subjects (217 with diabetes and 136 controls matched by age, sex, and cardiovascular risk factors) with normal resting ECG. The diabetic group included 39 type 1 and 178 type 2 diabetics (age 57 +/- 11 yr, 162 males/55 females). Subjects performed the Treadmill Test (TT) and, when abnormal, underwent single-photon emission computed tomography (SPECT) with exercise testing or dipyridamole injection. Coronary angiography was performed if the SPECT was suggestive of ischemia. TT was positive in 16 (8.5%) diabetics: 3 with type 1 and 13 with type 2. No controls had positive TT. SPECT was performed in 13 subjects and was positive in 10; angiography was performed in 7 and identified significant lesions in all cases. Patients with SMI were older and had a higher prevalence of autonomic neuropathy, hypertension, and dyslipidemia than those without. Microalbuminuria was also higher in the SMI group (613 +/- 211 vs 72 +/- 245 mg/d; p < 0.05). We conclude that diabetic patients aged over 60 with autonomic neuropathy and other cardiovascular risk factors should be screened for the presence of SMI especially if they have increased microalbuminuria.
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