ArticleGenes & development2005
A telomeric repeat sequence adjacent to a DNA double-stranded break produces an anticheckpoint.
Article in Genes & development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 73 citations in OpenAlex.
- Both genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells.Nature communications · 2026Article
- A Chromosome End Without Terminal Telomere Repeats is Stable for Multiple Cell Divisions.bioRxiv : the preprint server for biology · 2025Article
- A Chromosome End Without Terminal Telomere Repeats is Stable for Multiple Cell Divisions.microPublication biology · 2025Article
- A Rapidly Inducible DNA Double-Strand Break to Monitor Telomere Formation, DNA Repair, and Checkpoint Activation.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Ccq1 restrains Mre11-mediated degradation to distinguish short telomeres from double-strand breaks.Nucleic acids research · 2024Article
- To Fix or Not to Fix: Maintenance of Chromosome Ends Versus Repair of DNA Double-Strand Breaks.Cells · 2022Review
- Inhibition of MRN activity by a telomere protein motif.Nature communications · 2021Article
- A Heterochromatin Domain Forms Gradually at a New Telomere and Is Dynamic at Stable Telomeres.Molecular and cellular biology · 2018Article
- Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in Yeasts.Frontiers in genetics · 2016Article
- Rad9 interacts with Aft1 to facilitate genome surveillance in fragile genomic sites under non-DNA damage-inducing conditions in S. cerevisiae.Nucleic acids research · 2014Article
- Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.Current opinion in genetics & development · 2014Review
- Length-dependent processing of telomeres in the absence of telomerase.Nucleic acids research · 2014Article
- Regulation of telomere addition at DNA double-strand breaks.Chromosoma · 2013Review
- Suppression of chromosome healing and anticheckpoint pathways in yeast postsenescence survivors.Genetics · 2013Article
- Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance.Biomolecules · 2012Article
- Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end.Genetics · 2012Review
- Mec1p associates with functionally compromised telomeres.Chromosoma · 2012Article
- A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres.Molecular and cellular biology · 2012Article
- Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.Nature cell biology · 2012Article
- Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.Nature communications · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres are complex structures that serve to protect chromosome ends. Here we provide evidence that in Saccharomyces cerevisiae telomeres may contain an anticheckpoint activity that prevents chromosome ends from signaling cell cycle arrest. We found that an internal tract of telomeric repeats inhibited DNA damage checkpoint signaling from adjacent double-strand breaks (DSBs); cell cycle arrest lasted 8-12 h from a normal DSB, whereas it lasted only 1-2 h from a DSB adjacent to a telomeric repeat. The shortened or abridged arrest was not the result of DNA repair, nor reduced amounts of single-stranded DNA, nor of adaptation. The molecular identity of this telomere repeat-associated anticheckpoint activity is unknown, though it is not dependent upon telomerase or telomere-proximal gene silencing. The anticheckpoint may inhibit the ATR yeast ortholog Mec1 because Rad9 and Rad53 became dephosphorylated and inactivated during the abridged arrest. The anticheckpoint acts regionally; it inhibited signaling from DNA breaks up to 0.6 kb away from the telomeric repeat but not from a DSB present on a separate chromosome. We propose that after formation of the DSB near the telomeric repeat, a mature telomere forms in 1-2 h, and the telomere then contains proteins that inhibit checkpoint signaling from nearby DNA breaks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.