ArticleCirculation2005
Decreased microvascular nitric oxide-dependent vasodilation in postural tachycardia syndrome.
Article in Circulation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01308099 (Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome), which is not on this map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome (POTS)
Who cites it
29 citing papers in PubMed, 73 citations in OpenAlex.
- A double-blind placebo-controlled cross-over study of the vascular effects of midodrine in neuropathic compared with hyperadrenergic postural tachycardia syndrome.Clinical science (London, England : 1979) · 2014Trial
- Intradermal angiotensin II administration attenuates the local cutaneous vasodilator heating response.American journal of physiology. Heart and circulatory physiology · 2008Trial
- Nitric oxide and noradrenaline contribute to the temperature threshold of the axon reflex response to gradual local heating in human skin.The Journal of physiology · 2006Trial
- Revisiting the Venoarteriolar Reflex-Further Insights from Upper Limb Dependency in Healthy Subjects.Biology · 2024Article
- Impaired microvascular reactivity in patients treated with 5-fluorouracil chemotherapy regimens: Potential role of endothelial dysfunction.International journal of cardiology. Heart & vasculature · 2023Article
- Cutaneous manifestations of orthostatic intolerance syndromes.International journal of women's dermatology · 2021Article
- Baseline left ventricular ejection fraction associated with symptom improvements in both children and adolescents with postural tachycardia syndrome under metoprolol therapy.Chinese medical journal · 2021Article
- Supine Parasympathetic Withdrawal and Upright Sympathetic Activation Underly Abnormalities of the Baroreflex in Postural Tachycardia Syndrome: Effects of Pyridostigmine and Digoxin.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Impaired Endothelial Function in Patients With Postural Tachycardia Syndrome.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Association of Digoxin Application Approaches With Long-Term Clinical Outcomes in Rheumatic Heart Disease Patients With Heart Failure: A Retrospective Study.Frontiers in cardiovascular medicine · 2021Article
- Baseline Corrected QT Interval Dispersion Is Useful to Predict Effectiveness of Metoprolol on Pediatric Postural Tachycardia Syndrome.Frontiers in cardiovascular medicine · 2021Article
- Mechanisms of tilt-induced vasovagal syncope in healthy volunteers and postural tachycardia syndrome patients without past history of syncope.Physiological reports · 2019Article
- Moving from the present to the future of Postural Tachycardia Syndrome - What we need.Autonomic neuroscience : basic & clinical · 2018Review
- The role of shear stress on cutaneous microvascular endothelial function in humans.European journal of applied physiology · 2017Article
- Serum Resistin Negatively Correlates with Clinical Severity of Postural Tachycardia Syndrome in Children.Pediatric cardiology · 2017Article
- Body Mass Index (BMI) is Associated with the Therapeutic Response to Oral Rehydration Solution in Children with Postural Tachycardia Syndrome.Pediatric cardiology · 2016Article
- Baroreflex Sensitivity Predicts Short-Term Outcome of Postural Tachycardia Syndrome in Children.PloS one · 2016Article
- Blunted cerebral blood flow velocity in response to a nitric oxide donor in postural tachycardia syndrome.American journal of physiology. Heart and circulatory physiology · 2014Article
- Neuronal and hormonal perturbations in postural tachycardia syndrome.Frontiers in physiology · 2014Review
- Ascorbate improves circulation in postural tachycardia syndrome.American journal of physiology. Heart and circulatory physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOne variant of postural tachycardia syndrome (POTS), designated low-flow POTS, is associated with decreased peripheral blood flow related to impaired local vascular regulation. METHODS AND
resultsTo investigate the hypothesis that microvascular endothelial dysfunction produces decreased peripheral blood flow in low-flow POTS, we performed experiments using laser-Doppler flowmetry (LDF) combined with iontophoresis in 15 low-flow POTS patients, 17 normal-flow POTS patients, and 13 healthy reference volunteers varying in age from 14 to 22 years. We tested whether alpha-adrenergic vasoregulation was impaired using iontophoretic delivery of tyramine, phentolamine, and bretylium followed by a norepinephrine dose response. We tested endothelial-dependent and -independent receptor-mediated vasodilation by measuring acetylcholine and sodium nitroprusside dose responses. We tested whether nitric oxide-dependent vasodilation was different in these groups by testing the local thermal hyperemic response to saline used as a reference compared with the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME). Adrenergic and receptor-dependent cutaneous vasoregulation was similar for low-flow POTS, normal-flow POTS, and reference subjects. Thermal hyperemia produced distinctly different findings: there was marked attenuation of the nitric oxide-sensitive plateau during prolonged heating, which was insensitive to L-NAME in low-flow POTS subjects. The pattern of thermal hyperemia response in low-flow POTS subjects during saline administration resembled the pattern in reference subjects during L-NAME administration and was minimally affected by L-NAME.
conclusionsThe data suggest that flow-dependent nitric oxide release is reduced in low-flow POTS. This may account for local flow regulation abnormalities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.