ReviewNeurobiology of learning and memory2006
Gene targeting of presynaptic proteins in synaptic plasticity and memory: across the great divide.
Review in Neurobiology of learning and memory, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Article
- Genetic underpinnings of brain structural connectome for young adults.Journal of the American Statistical Association · 2023Article
- Ablation of the Presynaptic Protein Mover Impairs Learning Performance and Decreases Anxiety Behavior in Mice.International journal of molecular sciences · 2022Article
- Interaction of chronic intermittent ethanol and repeated stress on structural and functional plasticity in the mouse medial prefrontal cortex.Neuropharmacology · 2021Article
- Memory Function in Feeding Habit Transformation of Mandarin Fish (International journal of molecular sciences · 2018Article
- Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway.Neural plasticity · 2017Article
- Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC).Molecular & cellular proteomics : MCP · 2016Article
- Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degeneration.Biochimica et biophysica acta · 2014Article
- A presynaptic role for PKA in synaptic tagging and memory.Neurobiology of learning and memory · 2014Article
- Neuron-specific expression of tomosyn1 in the mouse hippocampal dentate gyrus impairs spatial learning and memory.Neuromolecular medicine · 2013Article
- Structural plasticity of climbing fibers and the growth-associated protein GAP-43.Frontiers in neural circuits · 2013Review
- Short-term forms of presynaptic plasticity.Current opinion in neurobiology · 2011Review
- Experience-dependent plasticity and modulation of growth regulatory molecules at central synapses.PloS one · 2011Article
- Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins.Neuron · 2010Review
- RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Tomosyn expression pattern in the mouse hippocampus suggests both presynaptic and postsynaptic functions.Frontiers in neuroanatomy · 2010Article
- PKA has a critical role in synaptic delivery of GluR1- and GluR4-containing AMPARs during initial stages of acquisition of in vitro classical conditioning.Journal of neurophysiology · 2009Article
- Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Natural polymorphism affecting learning and memory in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Presynaptic contributions of chordin to hippocampal plasticity and spatial learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The past few decades have seen an explosion in our understanding of the molecular basis of learning and memory. The majority of these studies in mammals focused on post-synaptic signal transduction cascades involved in post-synaptic long-lasting plasticity. Until recently, relatively little work examined the role of presynaptic proteins in learning and memory in complex systems. The synaptic cleft figuratively represents a "great divide" between our knowledge of post- versus presynaptic involvement in learning and memory. While great strides have been made in our understanding of presynaptic proteins, we know very little of how presynaptically expressed forms of short- and long-term plasticity participate in information processing and storage. The paucity of cognitive behavioral research in the area of presynaptic proteins, however, is in stark contrast to the plethora of information concerning presynaptic protein involvement in neurotransmitter release, in modulation of release, and in both short- and long-term forms of presynaptic plasticity. It is now of great interest to begin to link the extensive literature on presynaptic proteins and presynaptic plasticity to cognitive behavior. In the future there is great promise with these approaches for identifying new targets in the treatment of cognitive disorders. This review article briefly surveys current knowledge on the role of presynaptic proteins in learning and memory in mammals and suggests future directions in learning and memory research on the presynaptic rim of the "great divide."
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.