ArticleNeoplasia (New York, N.Y.)2005
Regulation of glioma cell migration by serine-phosphorylated P311.
Article in Neoplasia (New York, N.Y.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 61 citations in OpenAlex.
- Integrative RNA-seq and LASSO-COX analysis reveal Paeonol's key target gene in proliferation suppression and apoptosis-induced in cervical cancer.Frontiers in pharmacology · 2025Article
- NREP, transcriptionally upregulated by HIF-1α, aggravates breast cancer cell growth and metastasis by promoting glycolysis.Cell death discovery · 2024Article
- NREP is a Diagnostic and Prognostic Biomarker, and Promotes Gastric Cancer Cell Proliferation and Angiogenesis.Biochemical genetics · 2023Article
- [Effects of P311 on the angiogenesis ability of human microvascular endothelial cell 1 in vitro and its molecular mechanism].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- P311 promotes type II transforming growth factor-β receptor mediated fibroblast activation and granulation tissue formation in wound healing.Burns & trauma · 2022Article
- Molecular Mechanism of Mesenchyme Homeobox 1 in Transforming Growth Factor β1-InducedFrontiers in molecular biosciences · 2020Article
- Reconstruction and Functional Annotation of P311 Protein-Protein Interaction Network Reveals Its New Functions.Frontiers in genetics · 2019Article
- Transcriptomics Signature from Next-Generation Sequencing Data Reveals New Transcriptomic Biomarkers Related to Prostate Cancer.Cancer informatics · 2019Article
- EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival.Molecular cancer research : MCR · 2018Article
- Identification of miR-29b targets using 3-cyanovinylcarbazole containing mimics.RNA (New York, N.Y.) · 2018Article
- P311, Friend, or Foe of Tissue Fibrosis?Frontiers in pharmacology · 2018Review
- P311 Deficiency Leads to Attenuated Angiogenesis in Cutaneous Wound Healing.Frontiers in physiology · 2017Article
- nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer.Oncotarget · 2016Article
- Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway.Journal of neuro-oncology · 2016Article
- P311 promotes renal fibrosis via TGFβ1/Smad signaling.Scientific reports · 2015Article
- Significance of filamin A in mTORC2 function in glioblastoma.Molecular cancer · 2015Article
- Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor β1-3 (TGF-β1-3).The Journal of biological chemistry · 2014Article
- Circulating anti-filamin C autoantibody as a potential serum biomarker for low-grade gliomas.BMC cancer · 2014Article
- Differential expression of filamin A and its clinical significance in breast cancer.Oncology letters · 2013Article
- MeCP2 modulates gene expression pathways in astrocytes.Molecular autism · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
P311, an 8-kDa polypeptide, was previously shown to be highly expressed in invasive glioma cells. Here, we report the functional characteristics of P311 with regard to influencing glioma cell migration. P311 is constitutively serine-phosphorylated; decreased phosphorylation is observed in migration-activated glioma cells. The primary amino acid sequence of P311 indicates a putative serine phosphorylation site (S59) near the PEST domain. Site-directed mutagenesis of S59A retarded P311 degradation and induced glioma cell motility. In contrast, S59D mutation resulted in the rapid degradation of P311 and reduced glioma cell migration. Coimmunoprecipitation coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis identified Filamin A as a binding partner of P311, and immunofluorescence studies showed that both proteins colocalized at the cell periphery. Moreover, P311-induced cell migration was abrogated by inhibition of beta1 integrin function using TACbeta1A, a dominant-negative inhibitor of beta1 integrin signaling, suggesting that P311 acts downstream of beta1 signaling. Finally, overexpression of P311 or P311 S59A mutant protein activates Rac1 GTPase; small interfering RNA-mediated depletion of Rac1 suppresses P311-induced motility. Collectively, these results suggest a role for levels of P311 in regulating glioma motility and invasion through the reorganization of actin cytoskeleton at the cell periphery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.