ArticleNeoplasia (New York, N.Y.)2005
Epigenetic regulation of the cell type-specific gene 14-3-3sigma.
Article in Neoplasia (New York, N.Y.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- The Warburg effect: molecular aspects and therapeutic possibilities.Molecular biology reports · 2015Review
- Promoter methylation confers kidney-specific expression of the Klotho gene.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
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- Article
- Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells.PloS one · 2010Article
- Metabolic defects provide a spark for the epigenetic switch in cancer.Free radical biology & medicine · 2009Review
- The 14-3-3sigma gene promoter is methylated in both human melanocytes and melanoma.BMC cancer · 2009Article
- Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Effects of CpG methylation on recognition of DNA by the tumour suppressor p53.Journal of molecular biology · 2009Article
- Regulation of 14-3-3sigma expression in human thyroid carcinoma is epigenetically regulated by aberrant cytosine methylation.Cancer letters · 2008Article
- A review of the past, present, and future directions of neoplasia.Neoplasia (New York, N.Y.) · 2005Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
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Abstract
Epigenetic control participates in processes crucial in mammalian development, such as X-chromosome inactivation, gene imprinting, and cell type-specific gene expression. We provide evidence that the p53-inducible gene 14-3-3sigma is a new example of a gene important to human cancer, where epigenetic mechanisms participate in the control of normal cell type-specific expression, as well as aberrant gene silencing in cancer cells. Like a previously identified cell type-specific gene maspin, 14-3-3sigma is a p53-inducible gene; however, it participates in G2/M arrest in response to DNA-damaging agents. 14-3-3Sigma expression is restricted to certain epithelial cell types, including breast and prostate, whereas expression is absent in nonepithelial tissues such as fibroblasts and lymphocytes. In this report, we show that in normal cells expressing 14-3-3sigma, the 14-3-3sigma CpG island is unmethylated; associated with acetylated histones, unmethylated histone H3 lysine 9; and an accessible chromatin structure. By contrast, normal cells that do not express 14-3-3sigma have a methylated 14-3-3sigma CpG island with hypoacetylated histones, methylated histone H3 lysine 9, and an inaccessible chromatin structure. These findings extend the spectrum of cell type-specific genes controlled, partly, by normal epigenetic mechanisms, and suggest that this subset of genes may represent important targets of epigenetic dysregulation in human cancer.
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