ArticleThe Journal of chemical physics2005
Reactions on cell membranes: comparison of continuum theory and Brownian dynamics simulations.
Article in The Journal of chemical physics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions.Biophysical journal · 2019Article
- A spatio-temporal model reveals self-limiting FcRoyal Society open science · 2018Article
- A model-based analysis of tissue targeting efficacy of nanoparticles.Journal of the Royal Society, Interface · 2018Article
- A multiscale modeling study of particle size effects on the tissue penetration efficacy of drug-delivery nanoparticles.BMC systems biology · 2017Article
- Architecture and biogenesis of plus-strand RNA virus replication factories.World journal of virology · 2013Review
- Dynamics of enzymatic digestion of elastic fibers and networks under tension.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Analysis of reaction-diffusion systems with anomalous subdiffusion.Biophysical journal · 2009Article
- Signal transduction at point-blank range: analysis of a spatial coupling mechanism for pathway crosstalk.Biophysical journal · 2008Article
- Spatial regulation and the rate of signal transduction activation.PLoS computational biology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Biochemical transduction of signals received by living cells typically involves molecular interactions and enzyme-mediated reactions at the cell membrane, a problem that is analogous to reacting species on a catalyst surface or interface. We have developed an efficient Brownian dynamics algorithm that is especially suited for such systems and have compared the simulation results with various continuum theories through prediction of effective enzymatic rate constant values. We specifically consider reaction versus diffusion limitation, the effect of increasing enzyme density, and the spontaneous membrane association/dissociation of enzyme molecules. In all cases, we find the theory and simulations to be in quantitative agreement. This algorithm may be readily adapted for the stochastic simulation of more complex cell signaling systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.